Antiepileptic Drugs Flashcards by Sam Marcucci

Q

Phenytoin- focal or general?

A

Focal

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Q

Phenytoin- MOA

A

Na channels

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Q

Phenytoin- side effects

A

CYP-450, gingival hyperplasia, cleft palate, DIL

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Q

Carbamazepine- focal or general?

A

Focal

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Q

Carbamazepine- MOA

A

Na channels

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Q

Carbamazepine- side effects

A

Hyponatremia, neural tube defects, neutropenia, SJS, DIL

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Q

Oxcarbazepine- focal or general?

A

Focal

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Q

Oxcarbazepine- MOA

A

Na channels

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Q

Oxcarbazepine- side effects

A

Severe hyponatremia

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Q

Lacosamide- focal or general?

A

General

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Q

Lacosamide- MOA

A

Slow inactivation of Na channels

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Q

Lacosamide- side effects

A

PR prolongation- ECG first!

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Q

Eslicarbazepine- focal or general?

A

Focal

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Q

Eslicarbazepine- MOA

A

Na channels

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Q

Eslicarbazepine- side effects

A

Hyponatremia (less than others)

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Q

Levetiracetam- focal or general?

A

General

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Q

Levetiracetam- MOA

A

SVA-2

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Q

Levetiracetam- side effects

A

Grumpy

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Q

Brivaracetam- focal or general?

A

General

Q

Brivaracetam- MOA

A

SVA-2

Q

Brivaraceteam- side effects

A

Grumpy (less than LEV)

Q

Lamotrigine- focal or general?

A

General

Q

Lamotrigine- MOA

A

Slow Na channels, glutamate

Q

Lamotrigine- side effects

A

SJS

Lamotrigine- synergizes with which other AED?

Valproic acid

Clobazam- focal or general?

General

Clobazam- MOA

Benzodiazepine

When is clobazam used?

LGS or if BZDs highly effective

Ethosuximide- focal or general?

General/Absence

Ethosuximide- MOA

T-type Ca channels

Ethosuximide- side effects

DIL, nausea/vomiting

Topiramate- focal or general?

General

Topiramate- MOA

Na, GABA. Weak carbonic anhydrase inhibitor.

Topiramate- side effects

Anorexia, cognitive, nephrolithiasis

Zonisamide- focal or general?

General

Zonisamide- MOA

Na, GABA, weak carbonic anhydrase

Zonisamide- side effects

Less cognitive effects than TPM

Valproic acid- focal or general?

General

Valproic acid- MOA

Na, GABA, T-type Ca channels

Valproic acid- side effects

Hepatotoxicity

Gabapentin- focal or general?

Focal

Gabapentin- MOA

Ca channels

Gabapentin- side effects

Drowsiness, myoclonus

Felbamate- focal or general?

General

Felbamate- MOA

NMDA, GABA, Na

Felbamate- side effects

Inhibits metabolism of other AEDs, GI, aplastic anemia