Antiepileptic Drugs Flashcards by Sam Marcucci

Q

Phenytoin- focal or general?

A

Focal

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Q

Phenytoin- MOA

A

Na channels

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Q

Phenytoin- side effects

A

CYP-450, gingival hyperplasia, cleft palate, DIL

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Q

Carbamazepine- focal or general?

A

Focal

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Q

Carbamazepine- MOA

A

Na channels

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Q

Carbamazepine- side effects

A

Hyponatremia, neural tube defects, neutropenia, SJS, DIL

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Q

Oxcarbazepine- focal or general?

A

Focal

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Q

Oxcarbazepine- MOA

A

Na channels

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Q

Oxcarbazepine- side effects

A

Severe hyponatremia

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Q

Lacosamide- focal or general?

A

General

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Q

Lacosamide- MOA

A

Slow inactivation of Na channels

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Q

Lacosamide- side effects

A

PR prolongation- ECG first!

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Q

Eslicarbazepine- focal or general?

A

Focal

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Q

Eslicarbazepine- MOA

A

Na channels

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Q

Eslicarbazepine- side effects

A

Hyponatremia (less than others)

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Q

Levetiracetam- focal or general?

A

General

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Q

Levetiracetam- MOA

A

SVA-2

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Q

Levetiracetam- side effects

A

Grumpy

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Q

Brivaracetam- focal or general?

A

General

Q

Brivaracetam- MOA

A

SVA-2

Q

Brivaraceteam- side effects

A

Grumpy (less than LEV)

Q

Lamotrigine- focal or general?

A

General

Q

Lamotrigine- MOA

A

Slow Na channels, glutamate

Q

Lamotrigine- side effects

A

SJS

Q

Lamotrigine- synergizes with which other AED?

A

Valproic acid

Q

Clobazam- focal or general?

A

General

Q

Clobazam- MOA

A

Benzodiazepine

Q

When is clobazam used?

A

LGS or if BZDs highly effective

Q

Ethosuximide- focal or general?

A

General/Absence

Q

Ethosuximide- MOA

A

T-type Ca channels

Q

Ethosuximide- side effects

A

DIL, nausea/vomiting

Q

Topiramate- focal or general?

A

General

Q

Topiramate- MOA

A

Na, GABA. Weak carbonic anhydrase inhibitor.

Q

Topiramate- side effects

A

Anorexia, cognitive, nephrolithiasis

Q

Zonisamide- focal or general?

A

General

Q

Zonisamide- MOA

A

Na, GABA, weak carbonic anhydrase

Q

Zonisamide- side effects

A

Less cognitive effects than TPM

Q

Valproic acid- focal or general?

A

General

Q

Valproic acid- MOA

A

Na, GABA, T-type Ca channels

Q

Valproic acid- side effects

A

Hepatotoxicity

Q

Gabapentin- focal or general?

A

Focal

Q

Gabapentin- MOA

A

Ca channels

Q

Gabapentin- side effects

A

Drowsiness, myoclonus

Q

Felbamate- focal or general?

A

General

Q

Felbamate- MOA

A

NMDA, GABA, Na

Q

Felbamate- side effects

A

Inhibits metabolism of other AEDs, GI, aplastic anemia