Antiepileptic Drugs Flashcards

1
Q

Phenytoin- focal or general?

A

Focal

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2
Q

Phenytoin- MOA

A

Na channels

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3
Q

Phenytoin- side effects

A

CYP-450, gingival hyperplasia, cleft palate, DIL

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4
Q

Carbamazepine- focal or general?

A

Focal

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5
Q

Carbamazepine- MOA

A

Na channels

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6
Q

Carbamazepine- side effects

A

Hyponatremia, neural tube defects, neutropenia, SJS, DIL

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7
Q

Oxcarbazepine- focal or general?

A

Focal

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8
Q

Oxcarbazepine- MOA

A

Na channels

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9
Q

Oxcarbazepine- side effects

A

Severe hyponatremia

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10
Q

Lacosamide- focal or general?

A

General

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11
Q

Lacosamide- MOA

A

Slow inactivation of Na channels

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12
Q

Lacosamide- side effects

A

PR prolongation- ECG first!

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13
Q

Eslicarbazepine- focal or general?

A

Focal

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14
Q

Eslicarbazepine- MOA

A

Na channels

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15
Q

Eslicarbazepine- side effects

A

Hyponatremia (less than others)

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16
Q

Levetiracetam- focal or general?

A

General

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17
Q

Levetiracetam- MOA

A

SVA-2

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18
Q

Levetiracetam- side effects

A

Grumpy

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19
Q

Brivaracetam- focal or general?

A

General

20
Q

Brivaracetam- MOA

A

SVA-2

21
Q

Brivaraceteam- side effects

A

Grumpy (less than LEV)

22
Q

Lamotrigine- focal or general?

A

General

23
Q

Lamotrigine- MOA

A

Slow Na channels, glutamate

24
Q

Lamotrigine- side effects

A

SJS

25
Q

Lamotrigine- synergizes with which other AED?

A

Valproic acid

26
Q

Clobazam- focal or general?

A

General

27
Q

Clobazam- MOA

A

Benzodiazepine

28
Q

When is clobazam used?

A

LGS or if BZDs highly effective

29
Q

Ethosuximide- focal or general?

A

General/Absence

30
Q

Ethosuximide- MOA

A

T-type Ca channels

31
Q

Ethosuximide- side effects

A

DIL, nausea/vomiting

32
Q

Topiramate- focal or general?

A

General

33
Q

Topiramate- MOA

A

Na, GABA. Weak carbonic anhydrase inhibitor.

34
Q

Topiramate- side effects

A

Anorexia, cognitive, nephrolithiasis

35
Q

Zonisamide- focal or general?

A

General

36
Q

Zonisamide- MOA

A

Na, GABA, weak carbonic anhydrase

37
Q

Zonisamide- side effects

A

Less cognitive effects than TPM

38
Q

Valproic acid- focal or general?

A

General

39
Q

Valproic acid- MOA

A

Na, GABA, T-type Ca channels

40
Q

Valproic acid- side effects

A

Hepatotoxicity

41
Q

Gabapentin- focal or general?

A

Focal

42
Q

Gabapentin- MOA

A

Ca channels

43
Q

Gabapentin- side effects

A

Drowsiness, myoclonus

44
Q

Felbamate- focal or general?

A

General

45
Q

Felbamate- MOA

A

NMDA, GABA, Na

46
Q

Felbamate- side effects

A

Inhibits metabolism of other AEDs, GI, aplastic anemia