Antiemetics Flashcards
Droperidol Receptor
D2
Brand name for Droperidol
Inapsine
Droperidol dose
0.626 mg
Droperidol: Onset and Duration
Onset: 1-5 mins
Duration: 2 - 3 hours
Brand Name for Promethazine
Phenergan
Promethazine Receptor
- Histamine (H1)
- Muscarinic
- Dopamine
- Medullary Vomiting Center
Promethazine dose
6.25 - 25 mg
Promethazine Onset and Duration
Onset: 1-5 minutes
Duration: 4-6 hours
Brand name of Ondansetron
Zofran
Ondansetron Receptor
5-HT3
Ondansetron dose
4 mg
Ondansetron Onset and Duration
Onset: 10 mintes
Duration: 4-9 hours
Brand name for Dexmethasone
Decadron
Dexmethasone Receptor
Glucocorticoid Receptor (GR)
Dexmethasone Dose
4 mg
Dexmethasone onset and duration
Onset: 10 - 30 minutes
Duration: 2- 10 minutes
Brand name for Metoclopramide
Reglan
Metoclopramide Receptor
- D2
- 5-HT3
Metoclopramide Dose
10 - 20 mg
Metoclopramide Onset and Duration
Onset: 10 mins
Duration: 2 hours
Scopalamine Receptor
Muscarinic Antagonist
Scopalamine dose
Patch (0.3 - 0.65 mg)
Scopalamine Onset and Duration
Onset: 2-4 hours
Duration: 72 hours
Propofol Anti-emtic Receptor
- GABA (stimultes)
- 5-HT3 (reduces)
Propofol Anti-emetic dose
- 10 - 15 mg IV
- Followed by 10 mcg/kg/min infussion
PONV Risk Factors
- Female
- Age > 40
- Hx PONV or Motion Sickness
- Vertigo
Surgical PONV Risk Factors
- Laparoscopy
- Major Breast
- Strabismus
- Intraocular
- Middle Ear
- Tonsils
- Adenoids
- Neuro (Intracranial)
- Gynecologic
- Testicular
- Scrotum
- Kidney Stones
PONV Treatment Algorithm
Patient has 0 risk factors. What is the % chance of PONV and Treatment?
- 10 %
- Non-Pharmacological
PONV Treatment Algorithm
Patient has 1 risk factors. What is the % chance of PONV and Treatment?
- 20%
- 1 drug
PONV Treatment Algorithm
Patient has 2 risk factors. What is the % chance of PONV and Treatment?
- 40%
- 2 drugs
PONV Treatment Algorithm
Patient has 3 risk factors. What is the % chance of PONV and Treatment?
- > 60%
- 3+ drugs