Antiemetics

Question 1

Which antiemetic can be used for chemo and radiotherapy induced N/V and is less sedating?

Answer 1

Prochlorperazine

Question 2

Which antiemetic is used for N/V in palliative care?

Answer 2

Haloperidol

Question 2

Which antiemetic is less likely to cause central effects?

Answer 2

Domperidone - it does not cross the BBB

Central effects examples:
- sedation
- dystonic reactions

Question 3

Which antiemetic is used to treat N/V in parkinsons caused by dopaminergic drugs?

Answer 3

Domperidone

Question 4

Which anti-emetics are used to prevent N/V from cytotoxics?

Answer 4

Ondansetron
Granisetron
Palonosetron
Palonosetron with netupitant

Question 5

Which antiemetics are used in chemo-therapy induced N/V?

Answer 5

dexamethasone
aprepitant

Question 6

What drug can be considered as add-on therapy for chemotherapy induced N/V when unresponsive to conventional antiemetic?

Answer 6

Nabilone - a synthetic cannabinoid with antiemetic properties

Question 7

Which food can be helpful for pregnant women experiencing prolonged N/V?

Answer 7

Ginger

Question 8

Which antiemetic options are there for N/V in pregnancy?

Answer 8

Chlorpromazine
Metoclopramide
Cyclizine
Doxylamine with pyridoxine
Prochlorperazine
Promethazine *
Ondansetron

Question 9

Which antiemetics are used for post-operative N/V?

Answer 9

Granisetron
Ondansetron
Dexamethasone
Droperidol

Cyclizine - licensed for prevention and treatment of post-op N/V caused by opioids and general anaesthesia

Question 10

Which antiemetic is licensed for motion sickness?

Answer 10

Hyoscine
Antihistamines

Question 11

What is the MHRA warning for metoclopramide?

Answer 11

risk of neurological adverse effects - use only for 5 days
10mg TDS

Question 12

Which antiemetic should be avoided in GI problems or obstruction?

Answer 12

Metoclopramide
(3-4 days after GI surgery)

Question 13

What is the MHRA warning for ondansetron?

Answer 13

small increased risk of oral clefts following use in first 12 weeks of pregnancy