Antidotes to Toxicities, Side Effects and Overdoses

Question 1

Acetominophen Toxicity

Answer 1

N-Acetylcystine (replenishes glutathione-S)

Question 2

Salicylates (weak acid) Toxicity

Answer 2

Sodium Bicarbonate (alkalinize urine) + Dialysis

Question 3

Amphetamines (basic) Toxicity

Answer 3

NH4Cl (acidify urine)

Question 4

AchE-Inhibitors - Organophosphate (irreversible) Toxicity

Answer 4

Atropine (M-Ach-R Blocker), Pralidoxine

Question 5

B-Blockers Toxicity

Answer 5

Glucagon

Question 6

Digitalis Toxicity

Answer 6

KLAM = 
Normalize the K+
Lidocaine
Anti-dig Fab Fragments
Mg2+

Question 7

Iron Toxicity

Answer 7

Deferoxamine, Deferasirox

Question 8

Lead Toxicity

Answer 8

EDTA, Dimercaprol, Succimer, Penicillamine

Question 9

Mercury Hg2+, Arsenic, Gold Toxicity

Answer 9

Dimercaprol (BAL), Succimer

Question 10

Copper (Cu+), Arsenic, Gold Toxicity

Answer 10

Penicillamine

Question 11

Cyanide Toxicity

Answer 11

Nitritie + Thiosulfate, Hydroxycobalmin

Question 12

Methemoglobin Toxicity

Answer 12

Methylene Blue, Vitamin C (Reducing)

Question 13

Carbon Monoxide (CO) Toxicity

Answer 13

100% O2, Hyperbaric O2

Question 14

Methanol, Ethylene Glycol (antifreeze) Toxicity

Answer 14

Fomepizole > Ethanol, Dialysis

Question 15

Opioids Toxicity

Answer 15

Naloxzone, Naltrexone

Question 16

Benzodiazepines Toxicity

Answer 16

Flumazenil

Question 17

TCA’s (Weak acids) Toxicity

Answer 17

Sodium Bicarbonate (Alkalinize the blood)

Question 18

Heparin Toxicity

Answer 18

Protamine

Question 19

Warfarin Toxicity

Answer 19

Vitamin K, Fresh frozen plasma

Question 20

tPA, Streptokinase, urokinase Toxicity

Answer 20

Aminocaproic Acid

Question 21

Theophylline Toxicity

Answer 21

Beta-Blocker