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Pharmacology II Exam 2 > Antidotes II > Flashcards

Antidotes II Flashcards

1
Q

abnormality of regulation of heme synthesis in susceptible individuals

A

AIP

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2
Q

AIP attacks

A
  • severe abdominal pain
  • peripheral neuropathy
  • mental dysfunction
  • frequently fatal
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3
Q

AIP attacks precipitated by

A
  • certain drugs
  • steroids
  • starvation
  • infections
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4
Q

AIP genetic deficiency

A

porphonbolinogen deaminase

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5
Q

Drugs that cause AIP

A
  • barbiturates
  • anticonvulsants
  • ethanol
  • progestins
  • sulfonamides
  • glutethimide
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6
Q

AIP treatment

A

withdraw precipitating drug, confirm diagnosis

Hermatin: inhibits ALAS1 by reconstituting the hepatic heme pool (decrease porphyrin production)

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Pharmacology II Exam 2 (2 decks)

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