Antidirrhoetics Flashcards

1
Q

What are the main drugs prescribed to stop diarrhoea ?

A

Loperamide
Codeine
Morphine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Loperamide is the first line agent prescribed to stop diarrhoea. What is the mechanism of action?

A

Acts on the Mu receptors in the myenteric plexus
Decrease tone of the smooth muscles, reduces peristalsis but increases segmental contractions.
Decreases mass movement through suppressing the gastrocolic reflex.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Why might codeine and morphine be prescribed instead of loperamide?

A

Works on both Mu and delta receptors, therefore similar effects but also helps with pain relief

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are the side effects of codeine and morphine?

A

Paralytic ileus
N &V
Sedation and addiction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What lifestyle modifications can be made to improve loose stool?

A

Banana- high in K and fibre
White rice - bind stool
White bread/pasta- low in fibre

Limit fruit to 3 x day
Avoid caffeine, sorbitol, fatty, spicy food and fizzy drinks

Consider probiotics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What conditions may cause long term loose stools?

A
IBS
IBD
Short bowel
Hypermotility 
Drug side effects
How well did you know this?
1
Not at all
2
3
4
5
Perfectly