Antidepressants Flashcards
1
Q
Give two examples of an SSRI
A
Citalopram and Fluoxetine
2
Q
How do SSRIs work?
A
Increase levels of serotonin by inhibiting reuptake
3
Q
What are the contraindications of citalopram?
A
Poorly controlled epilepsy
Mania
4
Q
What must you be careful of when taking citalopram?
A
Prolonged QT syndrome
Hyponatraemia
5
Q
What are the key side effects of citalopram?
A
GI upset, sexual dysfunction, weight change, impaired concentration
6
Q
Give an example of an SNRI
A
Venflaxine, duloxetine
7
Q
What are the relative contraindications of taking an SNRI such as venflaxine?
A
Uncontrolled hypertension High risk of cardiac arrythmia Heart disease History of epilepsy History of mania
8
Q
What are the side effects of venlafaxine?
A
GI disturbance Headaches Palpitations Sexual dysfunction RARE but important: agranulocytosis, neuroleptic malignant syndrome, QT prolongation, serotonin syndrome
9
Q
How should the dose of venlafaxine be adjusted if the patient has reduced renal function?
A
Use half normal dose if eFR less than 30mL/minute/1.73m
