Antidepressants Flashcards
1
Q
What are symptoms of depression?
A
- depressed mood
- loss of interest or pleasure
- insomnia
- anorexia
- thoughts of suicide
- feelings of guilt, worthlessness
2
Q
Selective Serotonin Reuptake Inhibitors (SSRIs)
A
most commonly prescribed antidepressants
3
Q
SSRIs mechanism of action
A
- produce selective inhibition of serotonin reuptake
- produce CNS excitation
4
Q
SSRIs adverse effects
A
- serotonin syndrome
- insomnia
- somnolence
- drowsiness
- fatigue
- tremor
- asthenia
- increased risk of suicide
5
Q
SSRI drug interactions
A
- monoamine oxidase inhibitors
- antiplatelet drugs and anticoagulants
- asparin and NSAIDs
- warfarin
- TCAs and lithium
6
Q
SSRI nursing actions
A
- avoid alcohol and nonprescription drugs
- take fluoxetine or paroxetine early in day to prevent insomnia
- may begin to take effect in 1-4 weeks
- drug should be discontinued gradually
7
Q
Sertraline (Zoloft)
A
- blocks uptake of serotonin and dopamine
- CNS stimulation
- minimal effects on seizure threshold
8
Q
Paroxetine (Paxil, Paxil CR, Pexeva)
A
-inhibition of serotonin uptake
9
Q
Citalopram (Celexa)
A
- does not block receptors for serotonin, acetylcholine, norepinephrine, or histamine
- used for major depression
