Antidepressants Flashcards
Antidepressant Indications
Dysthymia, Major depression w/ melancholia & sychotic symptoms, Alcoholism, Schizophrenia, Intellectual development disorder, Depression with anxiety
Antidepressant Action
Increase the concentration of norepinephrine, serotonin, dopamine by blocking the reuptake of neurotransmitters
Antidepressant Contraindications
Not for pts with hypersensitivity
Not for pts in acute recovery phase of MIs
Not for pts w/ angle-closure glaucoma
* INCREASE RISK FOR SUICIDE IN CHILDREN & ADOLESCENTS
Caution if hepatic, renal, or cardia insufficiency, history of seizures, & prostatic hypertrophy
RN be alert of sudden lifts in mood (as depression decreases, suicide potential increases)
Antidepressant SE (General)
Dry mouth, Sedation, Nausea, Discontinuation syndrome, Priapism
Selective Serotonin Reuptake Inhibitors (SSRIs)
Citalopram (Celexa) Escitalopram (Lexapro) Fluoxetine (Prozac/Serafem) Fluvoxamine (Luvox) Paroxetine (Paxil) Sertraline (Zoloft) Vilazodone (Viibryd) Vortioxetine (Brintellix)
(SE) besides general SE - insomnia, agitation, HA, Weight loss, Sexual dysfunction, Serotonin syndrome
Monoamine Oxidase Inhibitors (MAOIs)
Isocarboxazid (Marplan)
Phenelzine (Nardil)
Tranylcypromine (Parnate)
Selegiline Transdermal System (Emsam)
(SE) besides general SE - Hypertensive crisis may occur with foods high in tyramine
Heterocyclics
Bupropion (wellbutrin) Maprotiline Mirtazapine (Remeron) Nefazodone Trazodone
SE besides general SE - Blurred vision, constipation, urinary retention, hypotension, reduction of seizure threshold, tachycardia, photosensitivity, weight gain
Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs)
Desvenlafaxine (Pristiq)
Levomilnacipran (Fetzima)
Duloxetine (Cymbalta)
Venlafaxine (Effexor)
(SE) besides general SE - insomnia, agitation, HA, Weight loss, Sexual dysfunction, Serotonin syndrome
Tricyclics
Amitriptyline Amoxapine Clomipramine (Anafranil) Desipramine (Norpramin) Doxepin Imipramine (Tofranil) Nortriptyline (Aventyl;Pamelor) Protriptyline (Vivactil) Trimipramine (Surmontil)
SE besides general SE - Blurred vision, constipation, urinary retention, hypotension, reduction of seizure threshold, tachycardia, photosensitivity, weight gain