Antidepressants

Question 1

Depression Pathophysiology

Answer 1

Monoamine Hypothesis - deficit in fx or amount of monoamines (DA, NE, Epi, 5-HT, etc)
Neurotrophic Hypothesis - altered neurotrophic and endocrine factors.

Question 2

Monoamine Physiology

Answer 2

Monoamine transporters
= DA transporter (DAT), (SERT), and (NET)
= reuptake into the pre-synaptic cleft to stop NT action
=> Degradation by MAO (monoamine oxidase)