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Antidepressants > Antidepressants > Flashcards

Antidepressants Flashcards

1
Q

Imipramine

A

TCA

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2
Q

Amitriptyline

A

TCA

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3
Q

Desipramine

A

TCA

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4
Q

Nortriptyline

A

TCA

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5
Q

Clomipramine

A

TCA

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6
Q

Maprotoline

A

TCA

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7
Q

Tranycypromine

A

MAOI

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8
Q

Phenelzine

A

MAOI

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9
Q

DI with MAOIs

A

Phenylpropanolamine, pseudoephedrine, meperidine

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10
Q

Selegiline

A

MAOI (B more than A)

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11
Q

Fluoxetine

A

SSRI

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12
Q

Paroxetine

A

SSRI

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13
Q

Sertraline

A

SSRI

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14
Q

Citalopram

A

SSRI

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15
Q

Escitalopram

A

SSRI

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16
Q

Venlafaxine

A

SNRI

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17
Q

Desvenlafaxine

A

SNRI

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18
Q

Duloxetine

A

SNRI

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19
Q

Levomilnacipran

20
Q

Bupropion

A

Mixed Action

21
Q

Mirtazapine

A

Mixed Action

22
Q

Trazodone

A

Mixed Action

23
Q

Vilazodone

A

Mixed Action

24
Q

Vortioxetine

A

Mixed Action

25
Q

1st generation antidepressants

A

TCAs and MAOIs

26
Q

2nd generation antidepressants

A

SSRIs, SNRIs, Mirtazapine, Bupropion

27
Q

TCA CIs

A

BPH, arrhythmias, narrow angle glaucoma, dementia

28
Q

TCA OD

A

lethal (cardiotoxic)

29
Q

Amitriptyline AEs

A

Anticholinergic, sedation, cardiotoxic

30
Q

Imipramine AEs

A

orthostatic hypotension, cardiotoxic

31
Q

TCA class AEs

A

anticholinergic, sedation, orthostatic hypotension, cardiotoxic, lower seizure threshold, weight gain

32
Q

Clomipramine max dose

A

250 mg due to seizure risk

33
Q

Serum drug concentrations with these antidepressants

A

TCAs (1 wk stable dose - trough 12 hours after last dose)

34
Q

SSRI and MAOI washout period

A

14 days, except Fluoxetine which is 5 weeks (long t1/2)

35
Q

“Cheese Reaction” symptoms

A

BP 220/130, HA, flushing, palpitations, diaphoresis, N/V

36
Q

SSRI AEs

A

Short term: HA, N/D, increased anxiety

Long term: weight gain, sexual dysfunction

37
Q

Citalopram max dose

A

40 mg qd due to QT prolongation

38
Q

Paroxetine AEs:

A

mild anticholinergic (avoid elderly), discontinuation syndrome (worst - requires tapering)

39
Q

Least discontinuation syndrome of SSRIs

A

Fluoxetine (no tapering needed)

40
Q

SSRI DIs

A 
Most with fluvoxamine, fluoxetine, sertraline
(class DI with tramadol and linezolid)
41
Q

Serotonin syndrome symptoms

A

(due to result of overstimulation of 5-HT1a) TRIAD: mental, autonomic, neurological - confusion, agitation, insomnia, fever, diaphroesis, myoclonus, tremor, hyperreflexia, cardiovascular collapse, coma, death

42
Q

Serotonin syndrome treatment

A

5-HT2A #s (cyproheptadine, olanzapine)

43
Q

SSRI AEs

A

Lethality, insomnia, anticholinergic, sexual dysfunction, increased blood pressure (don’t give venlafaxine, levomilnacipran to uncontrolled HTN patients), discontinuation syndrome (venlafaxine)

44
Q

Bupriopion AEs

A

Moderate agitation (peps people up), seizures (avoid if eating disorders or epilepsy)

45
Q

Mirtazapine and Trazodone AEs

A

severe sedation

46
Q

Trazodone AEs:

A

orthostasis, pripaism

Antidepressants (1 decks)

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