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Pharm Test 4 > Antidepressants 2 > Flashcards

Antidepressants 2 Flashcards

1
Q

Which two drug classes when given together cause Central Serotonin Syndrome? and what it is that syndrome?

A

MAOI +SSRI

fever, convulsions, death

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2
Q

What amine potentiates MAOIs and causes hypertensive crisis

A

tyramine

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3
Q

Tyramine is found in what foods

A

beer, cheese, wine, coffee, yeast, canned figs

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4
Q

MAOIs interfere with the metabolic degradation of what types of drugs

A

anesthesias, sedatives, analgesics, alcohol, anticholinergics, tricyclics, antihistamines

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5
Q

What three drugs are used to treat bipolar disorder

A

Lithium
Divalproex
Carbamazepine

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6
Q

Lithium needs to be given at ____concentration

A

high

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7
Q

Lithium has a HI/LOW therapeutic index?

A

LOW

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8
Q

What two anticonvulsants can be given to treat bipolar disorder

A

sodium valproate

Carbamazepine

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9
Q

Which antidepressants are the most cardiotoxic

A

tricyclics:

Imipramine and amitryptiline

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10
Q

tricyclics block what receptors

A

NE, 5HT, muscarinic, histamine, A2, A1

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11
Q

What are the side effects of tricyclics

A

dry mouth, constipation, decreased sweating, sedation, hypotension

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12
Q

Tricyclics are contraindicated in bipolar disorder TRUE/FALSE

A

TRUE; they cause mania

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13
Q

Which two drugs do not cause sexual dysfunction as a side effect

A

Buproprion and Mirtazapine

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14
Q

Which drug is used in smoking cessation

A

Buproprion

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15
Q

What are the side effects of Venlafaxine and Mirtazapine

A

Nausea, vomitting, headache, sexual dysfunciton

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16
Q

Which heterocyclic is also used as an anxiolytic

A

Mirtazapine

17
Q

SSRI’s mechanism

A

selectively target serotonins receptors only and block the reuptake of serotonin 5HT

18
Q

What are the side effects of SSRIs

A

nausea, vomitting, headache, sexual dysfunction

inhibit P450s: increases the plasma levels of other drugs**

19
Q

Which SSRI has the longest half life

A

Fluoxetine

20
Q

What are the SSRIs

A

Fluoxetine
Paroxetine
Setraline

21
Q

When giving lithium should a low NA diet be maintained

A

NOOOOO; HIGH salt diet

Pharm Test 4 (1 decks)

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