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psych pharm > Antidepressants > Flashcards

Antidepressants Flashcards

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1
Q

what are the TCAs

A

amitriptyline, nortriptyline, imipramine, clomipramine, desipramine, trimipramine, protriptyline,

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2
Q

what are the indications for TCAs

A

major depression, pain, anxiety disorders, ADHD, nocturnal enuresis, and schizophrenia

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3
Q

what are the adverse effects of the TCAs

A

orthostatic hypotension due to alpha 2 blockade, anti cholinergic effects, sedation, weight gain, sexual problems, acidosis. arrhythmias, delirium, and seizures,

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4
Q

what hypertension medication can TCAs block

A

clonidine

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5
Q

what are the other potential drug interactions with TCAs

A

competition for protein binding, CYP2D6, and other agents that increase seratonin

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6
Q

what are the pharmacokinetics of TCAs

A

they are highly protein bound and lipid soluble

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7
Q

amoxamine

A

D2 blocker and NET>SERT=DAT blocker used for psychosis with depression

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8
Q

maprotiline

A

selective NE re-uptake inhibitor with increased seizure risk

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9
Q

trazodone

A

5-HT2a antagonist and 5-HT1a partial agonist. used for depression with anxiety and sleep problems. CYP3A4.

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10
Q

mirtazepine

A

alpha 2 and 5-HT2 antagonist. increased NE and 5-HT. it is sedating due to potent anti histamine effects and it has worse weight gain. It has less GI and sexual problems

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11
Q

bupropion

A

weak blocker of DAT, SERT, and NET. Its metabolite is an NRI. it causes sympathetic side effects and can be used for smoking cessation. It can cause seizures

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12
Q

what are the SNRIs

A

duloxetine and venlafaxine

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13
Q

what are the issues with duloxetine

A

it is highly protein bound and it is metabolized by CYP2D6 and 1A2

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14
Q

vortioxetine

A

I don’t even care to type out all the shit that it does

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15
Q

what are the SSRIs

A

sertraline, paroxetine, fluoxetine, and citalopram

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16
Q

which of the SSRIs can cause birth defects

A

paroxetine

17
Q

which of the CYPs can TCAs inhibit

A

2C19 and 2D6

18
Q

what are the adverse effects of SSRIs

A

nausea and sexual side effects

19
Q

what is serotonin syndrome

A

when you have multiple drugs on board that all increase serotonin, the 5-HT1a receptors in the midbrain become overstimulated

20
Q

what are the MAOIs

A

tranylcypromine, isocarboxazid, and phenelzine

21
Q

what is the indication for MAOIs

A

used for depression when nothing else will work and for panic disorder and agoaphobia

22
Q

what are the drug interactions for MAOIs

A

anything that has tyramine in it, anything that will increase serotonin, and symapathetico mimetics

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