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Antidepressants > Antidepressants > Flashcards

Antidepressants Flashcards

1
Q

Mood stabilisers ( normontimic agents) are

A

Lithium ,carbamazepine,valproic acid ,Lamotrigine

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2
Q

Non cyclic monoamine reuptake inhibitors (NMARI) or tricyclic antidepressants are

A

Amitriptyline

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3
Q

selective serotonin reuptake inhibitors are

A

Paroxetine,citalopram,sertraline

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4
Q

Selective serotonin and norepinephrine reuptake inhibitors (SSNRI)are

A

Duloxetine and venlafaxine

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5
Q

Noradrenergic and specific serotininergic antidepressants (NaSSA) or tetracyclic antidepressants are

A

Mirtazapine

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6
Q

Selective dopamine and norepinephrine reuptake inhibitors are

A

Bupropion

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7
Q

Benzodiazepines are

A

Diazepam,alprazolam and midazolam

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8
Q

Non benzodiazepines are

A

Phenobarbital

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9
Q

Benzodiazepines analog

A

Zolpidem

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10
Q

Mood stabilisers are used for

A

Prophylactic purpose

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11
Q

Coanalgesia

A

Antidepressants used for enhance analgesic effect

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12
Q

In BD ,which signal transduction mechanism are affected

A

Intercellular and intracellular

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13
Q

Which signal transduction paths are affected by Li

A

IP3 signal path and Wnt signal path

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14
Q

Prerequisite for Li therapy is

A

Adequate renal fn

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15
Q

SE of Li

A

Tinnitus, aphasia, hypothyroidism, visual disturbance ,inhibit action of ADH in kidney

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16
Q

Tricyclic antidepressants have

A

Coanalgesic effect,so used in chronic neuropathic pain

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17
Q

Use of Tricyclic antidepressants (NMRI)

A

Major depression and chronic neuropathic pain

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18
Q

Tricyclic antidepressants overdose cose

A

Cardiotoxicity, convulsions and coma

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19
Q

Contraindications for tricyclic antidepressants are

A

Glaucoma

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20
Q

Effects of SNRI

A

Antidepressants,anxiolytic and coanalgesic

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21
Q

Use of SNRI

A

Major depression, chronic neuropathic pain, generalized anxiety disorder

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22
Q

SE of SNRI

A

Nausea, vomiting and sexual dysfunction

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23
Q

Duloxetine is a

A

SNRI(antidepressant and coanalgesic and anxiolytic)

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24
Q

Venlafaxine is a

A

SNRI(Antidepressants anxiolytic and coanalgesic )

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25
Q

SSRI use

A

major depression,panic and anxiety,OCD, Phobias

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26
Q

SE of SSRI

A

Nausea, vomiting and sexual dysfunction

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27
Q

SSRI can cause

A

Serotonin syndrome with MAOI and hemorrhage with new gen anticoagulants

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28
Q

SERT inhibition is done by

A

Tricyclic antidepressants,SSRI,SNRI

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29
Q

NET inhibition is done by

A

Tricyclic antidepressants,,SNRI, SDNRI,NaSSA

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30
Q

Anticholinergic effect

A

Amitriptyline (Tricyclic antidepressants)

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31
Q

Sedation is seen in

A

Tricyclic and tetracyclic AD(Amitriptyline,Bupropion)

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32
Q

Serotonin syndrome is caused by

A

SSRI,SSNRI,and Mirtazapine in less than 12 hours

33
Q

MAO inhibitor is

A

Selegiline

34
Q

Serotonin syndrome is caused by

A

Drug interactions

35
Q

Drug interacted to cause serotonin syndrome

A

Tryptophan, amphetamine,triptanes,MAO inhibitor selegiline

36
Q

Symptoms triad of serotonin syndrome

A

Hyperreflexia, neuromuscular disorders (tremor, rigidity),mental disorders

37
Q

Effects of ANS in serotonin syndrome

A

Tachycardia, tremor, hyperthermia, mydriasis, sweating

38
Q

Serotonin syndrome has

A

Hyperreflexia and mydriasis

39
Q

NMS has

A

Hyporeflexia and unchanged pupil

40
Q

Benzodiazepines are

A

Positive GABA modulator

41
Q

Flumazenil are

A

Negative GABA modulator

42
Q

BZD is

A

Anxiolytic

43
Q

BZD can cause

A

Thrombophlebitis

44
Q

Flumazenil is

A

BZD antagonist

45
Q

Diazepam effect

A

Anxiolytic,sedative,hypnotic,muscle relaxant, anticonvulsant

46
Q

Diazepam indication

A

Premedication of surgical procedures, seizures,muscle spasms, anxiety (sleep disorders)

47
Q

SE of Diazepam

A

Anterograde amnesia, respiratory depression, drowsiness

48
Q

Short acting BZD(1.5 to 2.5 h T1/2

49
Q

Use of midazolam

A

Introductory anesthesia, premedication of diagnostic and therapeutic procedures, seizures

50
Q

Effects of alprazolam

A

Anxiolytic, sedative, hypnotic, muscle relaxant

51
Q

Alprazolam use

A

Panic attack and anxiety, stress symptomatic therapy

52
Q

CI of alprazolam is

53
Q

Problems of BZD therapy

A

Addiction (within 2 tob3weeka upto 1 to 3 years, rebound effect, tolerance (after 1 month of treatment)

54
Q

Barbiturates are

A

Hypnotic or sedatives

55
Q

Barbiturates dependence leads to

A

Barbituromania

56
Q

Barbiturates act on

A

Beta subunit of GABAA

57
Q

BZD acts on

A

Alpha subunits 1-5 of GABAA

58
Q

Phenobarbital use

A

Cardiac neurosis,vegetative agitation,sleep disorders and epilepsy

59
Q

Benzodiazepines analog

60
Q

BZD analogy are

A

Zolpidem,acts only on alpha 1 subunit of GABAA

61
Q

Group z drugs have

A

Mainly hypnotic effect,mild muscle relaxant and antiepileptic activity,no anxiolytic effect

62
Q

Group z, zolpidem used for

A

Short term treatment for sleep disorders

63
Q

Zolpidem (group z)SE

A

Somnambulism (sleep walking) and hallucinations

64
Q

Hypnotic or sedatives overdose (BZD and analogue can be treated by

A

Flumazenil

65
Q

CNS depressients are potentiated by

66
Q

CI of carbamazepine is

67
Q

Carbamazepine use

A

Generalized epilepsy, bipolar disorders, neuropathy

68
Q

Carbamazepine blocks

A

Voltage gated sodium or calcium channel and decrease excitation

69
Q

Carbamazepine is a

A

Mood stabilisers and antiepileptic agents

70
Q

Valproic acid is an

A

Antiepileptic agents and mood stabilisers

71
Q

Moa of valproic acid

A

Blocks voltage gated sodium and calcium channel, inhibit GABA transaminase,inhibit excitation, anticonvulsant,mood stabilisers

72
Q

Use of valproic acid

A

Epilepsy, bipolar disorders and migraine prophylaxis

73
Q

CI of valproic acid

74
Q

Lamotrigine (antiepileptic and normontimic) action

A

Blocks sodium and calcium channel, decrease excitation

75
Q

Use of valproic acid

A

Epilepsy and bipolar disorders

76
Q

Depressive symptoms should be present for atleast

77
Q

Contraindications of amitriptyline and nortriptyline

78
Q

Epilepsy control agents

A

Carbamazepine, valproic acid, Lamotrigine,Gabapentin,Ethosuximide, phenobarbital,levetoracetam,Topiramate

79
Q

Medication to treat seizures

A

Diazepam,midazolam, valproic acid, phenobarbital, levetiracetam,,lorazepam

Antidepressants (1 decks)

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