Antidepressant Mechanisms of actions Flashcards
Citalopram
SSRI
most selective SSRI
s-isomer has pharmacological activity
Paroxetine
SSRI
Most potent of all SSRIs in serotinin reuptake blockade, but not specific, significant antimuscarin action
Fluvoxamine
SSRI
Escitalopram
SSRI
Venlafaxine
SNRI (serotonin and noradrenaline reuptake inhibitor)
acts as an SSRI in lower doses (<150mg)
Milnacipran
SNRI (serotonin and noradrenaline reuptake inhibitor)
Duloxetine
SNRI (serotonin and noradrenaline reuptake inhibitor)
Better profile for psychosomatic/neuropathic pain
Sibutramine
SNRI (serotonin and noradrenaline reuptake inhibitor)
Reboxetine
NARI- Noradrenaline reuptake inhibitor
Agomelatine
NDDI -Noradrenaline dopamine dishibitor
works via 5HT2C antagonism to enhane NA and DA neurotransmission
Mirtazapine
NaSSA- noradrenergic and specific serotonergic antagonist
5HT2A antagonist, alpha 2 antagonist, anti histaminic and anti 5HT3 properties
Buproprion
DARI- Dopamine reuptake inhibitor
used to help quit smoking and depression
increases efficiency of noradrenergic transmission
Moclobemide
RIMA- reversible inhibitor of Monoamine A oxidase
Trazodone
SARI- serotonin antagonist and reuptake inhibitor
5HT2a/2c antagonism and some alpha 2 blockade
Amoxapine
TCA
dopamine antagonist and serotonin-NA reuptake inhibition
Buspirone
Anxiolytic
Full serotonin 5HT1A agonist at presynaptic level inhibits release of serotonin (antianxiety effect)
Partial agonist of 5HT1a at post synaptic receptor (antidepressant activity)
Clomipramine
TCA
MOST potent. Higher serotonin reuptake inhib than other TCAs (but less than SSRIs)
Desipramine
TCA
Least anticholinergic action
lethal on overdose
Phenelzine
MAO-I
increases availability of monoamine incl serotonin and NA
Tranylcypromine
MOA-I
Buspirone
unique class - “azapirone”
full agonist at 5HT1A on presynamic receptor = antianxiety effects
partial agonist on post synaptic serotonin 5-HT1A receptors = antidepressant activity
Selegiline
selective MAO-B inhibitor
