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Paper A- pharmacology > Antidepressant Mechanisms of actions > Flashcards

Antidepressant Mechanisms of actions Flashcards

1
Q

Citalopram

A

SSRI
most selective SSRI
s-isomer has pharmacological activity

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2
Q

Paroxetine

A

SSRI

Most potent of all SSRIs in serotinin reuptake blockade, but not specific, significant antimuscarin action

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3
Q

Fluvoxamine

A

SSRI

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4
Q

Escitalopram

A

SSRI

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5
Q

Venlafaxine

A

SNRI (serotonin and noradrenaline reuptake inhibitor)

acts as an SSRI in lower doses (<150mg)

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6
Q

Milnacipran

A

SNRI (serotonin and noradrenaline reuptake inhibitor)

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7
Q

Duloxetine

A

SNRI (serotonin and noradrenaline reuptake inhibitor)

Better profile for psychosomatic/neuropathic pain

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8
Q

Sibutramine

A

SNRI (serotonin and noradrenaline reuptake inhibitor)

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9
Q

Reboxetine

A

NARI- Noradrenaline reuptake inhibitor

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10
Q

Agomelatine

A

NDDI -Noradrenaline dopamine dishibitor

works via 5HT2C antagonism to enhane NA and DA neurotransmission

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11
Q

Mirtazapine

A

NaSSA- noradrenergic and specific serotonergic antagonist

5HT2A antagonist, alpha 2 antagonist, anti histaminic and anti 5HT3 properties

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12
Q

Buproprion

A

DARI- Dopamine reuptake inhibitor
used to help quit smoking and depression
increases efficiency of noradrenergic transmission

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13
Q

Moclobemide

A

RIMA- reversible inhibitor of Monoamine A oxidase

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14
Q

Trazodone

A

SARI- serotonin antagonist and reuptake inhibitor

5HT2a/2c antagonism and some alpha 2 blockade

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15
Q

Amoxapine

A

TCA

dopamine antagonist and serotonin-NA reuptake inhibition

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16
Q

Buspirone

A

Anxiolytic
Full serotonin 5HT1A agonist at presynaptic level inhibits release of serotonin (antianxiety effect)
Partial agonist of 5HT1a at post synaptic receptor (antidepressant activity)

17
Q

Clomipramine

A

TCA

MOST potent. Higher serotonin reuptake inhib than other TCAs (but less than SSRIs)

18
Q

Desipramine

A

TCA
Least anticholinergic action
lethal on overdose

19
Q

Phenelzine

A

MAO-I

increases availability of monoamine incl serotonin and NA

20
Q

Tranylcypromine

A

MOA-I

21
Q

Buspirone

A

unique class - “azapirone”
full agonist at 5HT1A on presynamic receptor = antianxiety effects
partial agonist on post synaptic serotonin 5-HT1A receptors = antidepressant activity

22
Q

Selegiline

A

selective MAO-B inhibitor

Paper A- pharmacology (3 decks)

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