Antidepressant drugs Flashcards
Name an irreversible MAO inhibitor
Phenelzine
Name a reversible MAO inhibitor
Moclobemide
How do MAO inhbiotors act to increase neurotransmitter activity?
Prevent the conversion of NA or serotonin into their broken down counterparts
get more neurotransmitter in pre-synaptic area
More neurotransmitter will go into the synaptic cleft
What must people on phenelzine be cautious of and why?
Eating cheese
as it contains tyramine- a substance that can’t be broken down due to MAO-A inhibition in the gut
results in hypertensive crisis
Name some tricyclic antidepressants:
imipramine
dosulepin
amitriptyline
lofepramine
what is the mode of action of tricyclics?
Blocks the reuptake of monoamine neurotransmitters into presynaptic terminals
What are the common side effects of tricyclics?
Anticholinergic (blurry vision, dry mouth, constipation, urinary retention)
Sedation
Wgt gain
CVS (postural hypotension, tachycardia, arrhythmias)
Name some SSRIs
Fluoxetine
citalopram
sertraline
paroxetine
what is the mode of action for an SSRI?
selective inhibition of serotonin reuptake from the synaptic cleft
What are some common side effects of SSRIs
nausea headache sweating/vivid dreams worsened anxiety sexual dysfunction hyponatremia (elderly) under 25s= short term increase in suicidal ideation
What are some serotonin noradrenaine reuptake inhibitors?
Venlafaxine
duloxetine
What is the mode of action of an SNRI?
blocks the reuptake of both serotonin and noradrenaline into presynaptic terminals
what are some side effects of SNRIs?
nausea headache sweating worsened anxiety sexual dysfunction hyponatremia in elderly increased suicidal ideation initially in under 25s
Name a monoamine reuptake inhibitor that is more selective for NA?
Reboxetine
Name a monoamine reuptake inhibitor that may act on both presynaptic adrenoceptors and post synaptic serotonin receptors?
Mirtazepine
