Antidepressant Drugs

Question 1

How many symptoms are required for Major Depressive Episode?

Answer 1

> 5

Question 2

What two symptoms are required for at least 24hrs?

Answer 2

• depressed mood

- Markedly diminished interest or pleasure in all, or almost all, activities

Question 3

What is the most common psychiatric disorder worldwide?

Answer 3

Major depressive disorder (MDD)

Question 4

What two disorders is highly linked to suicide?

Answer 4

depression

biopolar disorder

Question 5

What is the 10th leading cause of death and 2nd leading cause of death in children in the U.S.?

Answer 5

Suicide

Question 6

Who is more prone to MDD?

Answer 6

females and adolescents

Question 7

What drug was used to make the antidepressant drug?

Answer 7

Chlorpromazine (Thorazine) (antipsyhotic)

Question 8

What was the first anti-depressant drug?

Answer 8

Imipramine (Tofranil)

Question 9

Imipramine structure?

Answer 9

3 ring

Question 10

Tricyclic drug (TCA) (tertiary amine)

Answer 10

-Imipramine

Question 11

Triyclic drug (secondary amine)

Answer 11

-Desipramine

Question 12

Selective Serotonin Reuptake Inhibitor (SSRI)

Answer 12

Fluoxetine

Question 13

Serotonin/ Norepi Reuptake Inhibitor (SNRI)

Answer 13

Duloxetine

Velafaxine

Question 14

Monoamine Oxidase Inhibitor (MAOI)

Answer 14

Phenelzine

Question 15

What is the MOA of TCA (tertiary amine)?

Answer 15

NE/5HT uptake

Question 16

What is the MOA of TCA (secondary amine)?

Answer 16

NE uptake

Question 17

What is the MOA of SSRI?

Answer 17

5-HT Uptake

Question 18

What is the MOA of SNRI?

Answer 18

Duloxetine- 5HT/NE uptake
Venlafaxine:
Lower doses- 5HT Uptake
High doses- 5HT/NE Uptake

Question 19

What is the MOA of MAOI?

Answer 19

Irreversible inhibition of MAO

Question 20

What class of drugs is no longer used in the U.S.?

Answer 20

Monoamine Oxidase Inhibitor (MAOI)

Question 21

If symptoms return with 5HT depletion what drug should be used to txt pt?

Answer 21

SSRI

Question 22

If symptoms return with NE depletion what drug should be used to txt pt?

Answer 22

NRI

Question 23

What is the unusually property of Tranlycypromine (MAOI)?

Answer 23

break one bond and can get amphetamine.

Question 24

Number Needed to Treat (NNT)

Answer 24

Measurement of the number of patients needed to be treated to have an impact (positive or neg) on ONE patient

Question 25

What reduces the risk of reoccurrence?

Answer 25

continuation therapy

Question 26

T/F psychiatric drugs have comparable efficacy to those in general medicine?

Answer 26

TRUE

Question 27

What is treatment of depression based on?

Answer 27

drug's tendency to evoke a particular constellation of side effects

Question 28

What sde are associated with muscarinic receptor?

Answer 28

- Dry mouth - urinary retention - blurry vision - constipation - memory impairment - sexual dysfunction

Question 29

What sde are associated with H1 histaminergic?

Answer 29

- sedation | - weight gain

Question 30

What sde a1 adrenergic?

Answer 30

- orthostatic hypotension | - sexual dysfunction

Question 31

What is used in overdose?

Answer 31

TCA

Question 32

What is unique about Selegline?

Answer 32

it can be delivered transdermal

Question 33

Why is Selegline transdermal used?

Answer 33

allows for greater inhibition of MAO in brain than in gut

Question 34

What side effect is associated with SSRI?

Answer 34

- Nausea - Weight gain - Asthenia - Sexual dysfunction - Somnolence

Question 35

5-HT2c and 5-HT1b side effect?

Answer 35

Satiation/ weight loss

Question 36

5-HT3 side effect?

Answer 36

nausea/ vomiting

Question 37

5-HT2 side effect?

Answer 37

anxiety, insomnia, agitation, sexual dysfunction