Anticuagulation Flashcards
What is the MOA of aspirin
irreversible inhibition of cyclooxegenase
what is the onset of aspirin
1-4 hours
what is the lifespan of a platelet?
10 days
what is the maximal effective dose of aspirin for preventative reasons?
160mg daily. every disease has an amount that is recommended
what is the purpose of dipyridamole?
secondary prevention of TIA and stroke
what is the MOA of dipyridamole:
inhibit cAMP inhibiting platelets and leading to vasodilation
how is dipyridamole usually administered?
in combination with low dose aspirin
what are symptoms of dipyridamole toxicity
Headache, and bleeding
what is the only anti-platelet agent that reversibly binds to platelets?
ticagrelor
how is clopidogrel usually dosed?
with a loading dose then maintainence dose.
how soon does clopidogrel start to work
after repeated dosing.
how long is clopidogrel effective for
up to 7 days of last dose
are antiplatelet drugs safe for renal patients
generally yes. especially clopidogrel
how long does it take to get to steady state for clopidogrel?
3-7 days
what drugs can attenuate the effects of clopidogrel?
macrolids, atorvastatin, and simvastatin
aside from bleeding, what is another risk/sign of toxicity in clopidogrel
thrombocytopenic purpura TTP
at what point in clopidogrel dosing can TTP occur?
within the first weak of treatment as you start getting to steady state
which drug has more bleeding risk and effectiveness? clopidogrel of prasugrel
prasugrel
what are the ADEs of prasugrel?
bleeding, abnormal LFTs, thrombocytopenia, anemia
why is ticagrelor uncommon in primary practice?
it has short duration of action, is recersible and has many CYP3A4 interactions
which antiplatelet drug causes dyspnea?
ticagrelor
what clotting factor is inhibited with low molecular weight heparin?
factor Xa
what are the two LMWHs
lovenox/enoxaparin, Fragmin (dalteparin)
what factors should be considered when determining the dose of LMWH drugs?
weight, renal function indication (prophylaxis or treatment
