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2074 - Nerveux III > Anticonvulsivants > Flashcards

Anticonvulsivants Flashcards

1
Q

MA de la phénytoïne

A

Prolongation inactivation des Na+

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2
Q

MA de la cabamazépine

A

Prolongation inactivation des Na+

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3
Q

MA de l’Ethosuximide

A

Blocage sélectif canaux Ca2+ T

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4
Q

MA du phénobarbital

A

Activation directe et modulation récepteurs GABA

Blocage canaux Ca2+ L et N

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5
Q

MA BZP

A

Modulation récepteurs GABAa

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6
Q

MA acide valproïque

A

Mal connu

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7
Q

MA Lamotriginne

A

Prolongation de l’inactivationn des canaux Na+ et Ca2+ N et P
Blocage récepteurs AMPA

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8
Q

MA Oxcarbazépine

A

Prolongation inactivation canaux Na+
Blocage canaux Ca2+
Augmentation conductance canaux K+

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9
Q

MA vigabatrine

A

Inhibe dégradation GABA (via inhibition GABA-transaminase)

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10
Q

MA tiagabine

A

Inhibe recapture GABA

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11
Q

MA gabapentin/prégabaline

A

Peu connnu

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12
Q

Ma topiramate

A

Action complexe
Blocage canaux Na+, récepteurs AMPA et kaïnite
Action GABA mimétique

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13
Q

MA lévétiracétam/brivaracetam

A

Liaison à SV2A, protéine des vésicules synaptiques

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14
Q

MA lacosamide

A

Prolongation inactivation « lente » des canaux Na+ voltage-dépendants

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15
Q

MA rufinamide

A

Inactivation canaux Na+ voltage-dépendant

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16
Q

MA perampanel

A

Blocage récepteurs AMPA

17
Q

MA eslicarbazépine

A

Prolongation inactivation canaux Na+
Blocage canaux Ca2+
Augmentation conductance canaux K+

18
Q

MA ezogabine

A

Activation canaux K+ KCNQ/Kv7 voltages dépendants

19
Q

Quels sont des INDUCTEURS des 2C

A

Phénytoïne
Carbamazépine
Phénobarbital
Eslicarbazépine

20
Q

Quels sont des INDUCTEURS des 3A

A 
Phénytoïne
Carbamazépine
Phénobarbital
Oxcarbazépine
Topiramate
21
Q

Quels sont des INHIBITEURS des 2C

A

Acide Valproïque
Oxcarbazépine
Topiramate

22
Q

Quel est INHIBITEUR des UGT

A

Acide valproïque

23
Q

Quels sont les anticonvulsivants de 1ère ligne?

A 
Phenytoïne
Carbamazépine
Acide valproïque
Ethosuximide
Lamotrigine
Oxcarbazépine

2074 - Nerveux III (1 decks)

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