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Wk 4 Ch 9 Antiepileptic Drugs In Psychiatry > Anticonvulsant Mood Stabilizers > Flashcards

Anticonvulsant Mood Stabilizers Flashcards

1
Q

Anticonvulsant medication’s effective in the treatment of acute mania

A

Divalproex sodium (valproate) and carbamazepine

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2
Q

Three anticonvulsants used for bipolar

A

Divalproic acid, carbamazepine and lamotrigine

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3
Q

Acute anti-manic medication

A

Valproic acid (even in cases were lithium treatment previously failed)

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4
Q

not approved by the FDA for maintenance treatment of bipolar With growing evidence in this favor of it

A

Valproate

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5
Q

While ____ is more affective than____ In the prevention of depressive episodes,___ appears to be more effective then ___ In preventing manic episodes

A

Lamotrigine
Lithium
Lithium
Lamotrigine

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6
Q

How Valproic acid is metabolized by the hepatic—— system

A

CYP2D6

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7
Q

Drugs that inhibit the CYP system (SSRIs) can cause an increase in-____levels

A

Valproic acid

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8
Q

What medication can increase the plasma levels of lamotrigine

A

Valproate

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9
Q

Common initial side effects of valproic acid

A

Nausea tremor and lethargy

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10
Q

Potentially fatal hepatic failure or pancreatitis can be caused by

A

Valproic acid

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11
Q

Symptoms of hepatic failure

A

Malaise weakness lethargy edema anorexia vomiting

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12
Q

How does lamotrigine work?

A

Appears to block certain gated sodium channels and decrease presynaptic release of glutamate

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13
Q

Carbamazepine is metabolized by the hepatic ____

A

CYP2D6

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14
Q

Concomitant administration of drugs that inhibit the CYP system will increase plasma levels of_________

A

Carbamazepine

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15
Q

Carbamazepine frequently causes

A

Lethargy, sedation, nausea, tremor, ataxia, visual disturbances during the acute treatment phase

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16
Q

Rare side effect of carbamazepine

A

Aplastic anemia or agranulocytosis

17
Q

This medication has been known to cause fetal anomalies, Spina bifida, small head circumference, so intraventricular conduction, inappropriate secretion of antidiuretic hormone, hyponatremia, decrease thyroid hormone levels, Steven Johnson’s, hepatitis

A

Carbamazepine

18
Q

Classic side effects form lithium

A

Nausea and diarrhea

Wk 4 Ch 9 Antiepileptic Drugs In Psychiatry (2 decks)

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