Anticoagulation and Antiplatelet Drugs

Question 1

P2y12 Receptor Antagonists Dboule MOA to suppress Platelet Activation/aggregation

Answer 1

• Prevent Glyco 2B/3a

- Block COX-1

Question 2

Clopidogrel, Prasugrel, Ticagrelor, and Cangrelor are all _____ _____ Antagonists

Answer 2

P2y12 Receptor

Question 3

Protamine reverses which drug’s effects?

Answer 3

Unfractionated Heparin

Question 4

3 Main uses of UFHeparin

Answer 4

1. Unstable Angina
2. Acute MI
3. Venous Thromboembolis

Question 5

2 Indications for Rivaroxaban Direct Xa Inhib?

Answer 5

Prevent Stroke or Treat VTE

Question 6

Out of the 4 P2Y12R antagos, which are IRR?

Answer 6

Clopi and Prasu

Question 7

Alteplase is a mimic of _____ _____

Answer 7

Human Tissue Plasminogen Activator (t-PA)

Question 8

Vorapaxar MOA

Answer 8

PAR-1 Thrombin Receptor Inhibitor (stop platelet aggreg)

Question 9

3 Gp2b/3a inhibitors

Answer 9

1. Abciximab
2. Eptifabatide
3. Tirofiban

Question 10

Aspirin is a permanent _____ inhibitor, via ACETYLATION

Answer 10

COX-1

Question 11

2 Main contraindications of Alteplase (TPA).

Answer 11

1. Head/Brain Bleeds

2. Active Bleed

Question 12

Warfarin MOA

Answer 12

Inhibits Vitamin K Reductase (VKOR)

Question 13

2 main toxicities of UFHeparin

Answer 13

1. Bleeding

2. Thrombocytopenia

Question 14

t-PA function

Answer 14

Lyse thrombi

Question 15

Aspirin blocks COX-1, which blocks _____ production and Platelet aggregation

Answer 15

TxA2

Question 16

Prototypical Direct Xa inhibitor that reduces Thrombin generation, platelet aggregation, and fibrin formation.

Answer 16

Rivaroxaban

Question 17

Prototypical VKOR inhibitor

Answer 17

Warfarin

Question 18

6 Clotting factors that need Vitamin K (Warfarin’s Target)

Answer 18

• 2
• 7
• 9
• 10
• Protein C
• Protein S

Question 19

Streptokinase 2 MOA

Answer 19

• turn Plasminogen into plasmin

- Degrade fibrin

Question 20

How to reverse Unfractionated Heparin?

Answer 20

Protamine

Question 21

Why are people so “fond” of Fondaparinux?

Answer 21

It can be safely used with pts with history of Hep-induced thrombocytopenia

Question 22

2 main Indication of Aletplase (TPA)

Answer 22

1. Severe DVT or PE

2. Ischemic Stroke

Question 23

Out of the 4 P2Y12R antagos, which are Reversible?

Answer 23

Tica and Cangre

Question 24

Gp2b/3a inhbit 2 indications

Answer 24

1. STEMI

2. (only Tiro) Non-ST elevation

Question 25

4 P2Y12 Receptor Antagonists

Answer 25

1. Clopidogrel 2. Prasugrel 3. Ticagrelor 4. Cangrelor

Question 26

Prototypical Thrombin site blocker that reks Fibrin formation, platelet activation, and suppresses feedback goag

Answer 26

Dobigatran

Question 27

Dobigatran 2 MOA

Answer 27

Competetively and Reversibly block Thrombin | - Less Fibrin formation

Question 28

Abciximab, eptifabatide, and Tirofiban are all _______ inhibitors

Answer 28

Gp 2b/3a inhibs

Question 29

2 LMW Heparin

Answer 29

1. Enoxaparin | 2. Fondaparinux

Question 30

Enoxaparin and Fondaparinux are both _______

Answer 30

LMW Heparin

Question 31

Rivaroxan MOA

Answer 31

Direct Xa Inhibitor

Question 32

Anistreplase MOA

Answer 32

- human plasminogen and streptokinase activation | fibinolytic

Question 33

Unfractionated heparin triple MOA

Answer 33

1. Irrev Bind AntiThrombin 2. Inhibit Factor 2a 3. Inhibit Factor Xa

Question 34

UFHep vs LMW Hep MOA

Answer 34

LMW only inbhibits Factor Xa, NOT THROMBIN