Anticoagulants, antiplatelets and fibrinolytics

Question 1

Name the antiplatelets?

Answer 1

Tirofiban
Clopidogrel
Aspirin
Ifetroban

Question 2

Tirofiban mechanism of action and side effects?

Answer 2

Blocks the GPIIb/IIIa receptor (expression increased by ADP and TXA2) on platelets preventing fibrin linking platelets together.

Question 3

Clopidogrel mechanism of action and side effects?

Answer 3

Irreversibly blocks ADP receptors preventing activation of further platelets.

Question 4

Aspirin mechanism of action and side effects?

Answer 4

Blocks COX1 preventing TXA2 synthesis.

Question 5

Ifetroban mechanism of action and side effects?

Answer 5

Blocks Thromboxane Synthase preventing TXA2 synthesis.

Question 6

Name the anticoagulants?

Answer 6

Warfarin
Heparin
LMWH
Rivaroxaban 
Fondaparinux
Dabigatran

Question 7

Warfarin mechanism of action and side effects?

Answer 7

Prevents activation of factors II, VII, IX and X.

Question 8

Heparin mechanism of action and side effects?

Answer 8

Inactivated factors IIa (Thrombin) and Xa.

Question 9

LMWH mechanism of action and side effects?

Answer 9

Inactivates factor Xa.

Question 10

Rivaroxaban mechanism of action and side effects?

Answer 10

Directly inhibits factor Xa.

Question 11

Fondaparinux mechanism of action and side effects?

Answer 11

Inactivates factor Xa.

Question 12

Dabigatran mechanism of action and side effects?

Answer 12

Directly inhibits factor IIa.

Question 13

Name the fibrinolytics?

Answer 13

Streptokinase
Alteplase
Duteplase
Tissue Plasminogen Activator