Anticoagulants + Antiplatelets Flashcards
When are anticoagulants used
Why
Venous thrombosis treatment and prevention
Venous thrombus consist more of fibrin than platelets due to slow flow
What is Thrombosis
Formation of solid mass of blood within circulatory system during life
What causes thrombosis
Virchows triad:
Abnormal blood flow (stagnation in venous)
Abnormal vessel wall (atheroma in arteries)
Abnormal blood components (post-op)
When are antiplatelets used
Why
Arterial thrombosis
Arterial thrombus consists of platelets>fibrin due to high flow
What are the types of anticoagulants
Warfarin Heparin Selective FXa inhibitor Direct thrombin inhibitor NOACs
What is the mechanism of action of warfarin
Inhibit synthesis of Vitamin K dependent clotting factors: II, VII, IX, X
by competitive antagonism of Vitamin K Reductase
(Inhibit activation of Vitamin K, inhibit carboxylation of glutamate required for CF synthesis)
What are indications of warfarin
INR 2-3
DVT
PE
AF
INR 2.5-4.5
Mechanical heart valve
Thrombosis with inherited thrombophilia
Recurrent thrombosis on warfarin
What are PK properties of warfarin
Good oral bioavailability (oral admin)
Slow onset/offset (heparin cover, stop 3 days)
Hepatic CYP450 metabolism (DIs)
Heavily protein bound (DIs)
Crosses placenta (teratogenic, brain haemorrhage)
How is warfarin administered
Oral - good bioavailability
Why does warfarin have slow onset/offset
How do you manage this
It takes several days for already synthesised CF to break down/new CF to be synthesised
Initial heparin cover
Withdraw 3 days prior to surgery
What effects does warfarin crossing the placenta have
Teratogenicity in 1st trimester
Brain haemorrhage in 3rd trimester
What drug interactions occur with warfarin
CYP450 enzyme inducers/inhibitors
Heavily protein bound drugs
What monitoring is required for warfarin
INR: international normalised ratio
To adjust dose
What is INR
PT/APTT
Measure of time take for blood to clot compared to average for age+gender
What types of interactions can occur with warfarin
Potentiating: Increased anticoagulatory effect
Inhibiting: decreased anticoagulatory effect
What causes potentiating DIs
CYP450 inhibitors: amiodarone, quinolone, metronidazole, acute alcohol binge, cimetidine
Heavily protein bound drugs: NSAIDs
What causes inhibiting DIs
CYP450 inducers: antiepileptics, rifampicin, St Johns wort, chronic alcohol
What are side effects of warfarin
Bleeding: epistaxis, GI bleed (unexplained anaemia), intracranial haemorrhage
Teratogenicity