Anticoagulants and Atrial fibrillation

Question 1

What is Haemostasis

Answer 1

= refers to the stopping of bleeding

3 stages

1. vascular spasm
2. platelet aggregation and plaque formation - antiplatelet drugs
3. coagulation (thrombus, clot) - Anticoagulant drugs

Question 2

Anticoagulant action drugs?

Answer 2

• warfarin
• heparin
• oral anticoagulants (dabigatran, apixaban, rivaroxaban)

Question 3

MOA of warfarin

Answer 3

= inhibits synthesis of Vit K dependent clotting factors

Question 4

WARFARIN

Answer 4

learn table

Question 5

Atrial fibrillation

Answer 5

= cardiac dysrhythmia —> very fast, disorganised electrical activity in atrial that is not sinus rhythm

	- not effective atrial contraction, quivers faster than 300 per min
	- can be a symptomatic or breathlessness, dizziness, thumping heartbeat

Question 6

Treatment of atrial fibrillation

Answer 6

1. Rate or rhythm control
   - rhythm control: reversion to and maintenance of sinus rhythm
   - rate control: control ventricular rate and increase refractory period of AV node
2. Anticoagulants to reduce risk of thrombi formation and this ischaemic stroke