Anticoagulants And Antiplatelets Flashcards
Coagulation cascade
Intrinsic or extrinsic pathways lead to formation of fibrin clot
Steps of coagulation cascade
◦Injured cells release prothrombin activator
◦Prothrombin activator changes prothrombin to thrombin.
◦Thrombin changes fibrinogen to fibrin
◦Fibrin forms insoluble web over injured area to stop blood flow
Fibrinolysis
•Clot removal
•Initiated by release of tissue plasminogen activator (tPA)
◦tPA converts plaminogen to plasmin
◦Plasmin digests fibrin strands – thus, circulation is restored
◦Regulated so unwanted clots are removed and fibrin is left in wounds
Antiplatelet medications
•Interferes with platelet aggregation, prolonging bleeding time
•Platelet aggregation occurs after vasoconstriction
•Platelets give off enzymes that cause increased platelet activity
◦ADP, Thromboxane A2 (TXA2)
•Antiplatelet medication affects ADP and TXA2
Common antiplatelet medications
◦aspirin (ASA)
◦ticlopidine (Ticlid)
◦clopidogrel (Plavix)
Antiplatelet contraindications
•Underlying bleeding disorders •Severe liver impairment •Any active bleeding •Pregnancy •Aspirin = “allergic triad” caution with renal or otic disease gout
Antiplatelet adverse effects
•Bruising and petechiae •GI include: N/V/D and pain •Headache dizziness weakness •Aspirin=hearing changes •Watch for anaphylactic reactions •Watch for platelet number ◦thrombocytopenia
Antiplatelet nursing implications
- Important history and physical before giving medications
- Monitor intake and output (dehydration)
- Watch for bleeding
- Discontinue medications 7 – 10 days prior to surgery, dental work
- Watch for hearing loss, dizziness, LOC changes
Antiplatelet patient teaching
- Teach patients to avoid any activity that would increase bleeding
- GI bleeding symptoms as well as any other bleeding
- Teach patient to take ASA with food to decrease stomach upset
Antiplatelet therapeutic use
Prevent clot formation
Anticoagulation medications
- Prolongs bleeding by interfering with the clotting cascade
* Given when patient has a high risk of developing thrombosis
Warfarin action
•warfarin:
Interferes with the vitamin K dependent factors by reducing synthesis of vitamin K
Heparin action
•heparin:
prevents conversion of prothrombin to thrombin and the conversion of fibrinogen to fibrin
Coumadin specific points
◦Atrial fib, CHF, valvular disease, pulmonary embolus, deep vein thrombosis
◦Takes 3 to 5 days for therapeutic dose
◦Long term treatment ORAL
Heparin specific points
•Heparin
◦Quick onset, used with emergencies with the above, also with procedures pregnancy
◦DIC
◦Intravenous and subcutaneous, short half life