Anticoagulants

Question 1

Heparin mechanism

Answer 1

Binds ATIII inhibiting thrombin(IIa) and Xa

Question 2

Heparin metabolism

Answer 2

Hepatic

Question 3

Heparin reversal

Answer 3

Protamine sulfate

Question 4

LMWH mechanism

Answer 4

Binds both ATIII and thrombin –> greater Xa than IIa (thrombin) inhib

Question 5

LMWH metabolism

Answer 5

Rental

Question 6

LMWH reversal

Answer 6

Protamine sulfate (partial)

Question 7

Fondaparinux mechanism

Answer 7

Xa indirect inhib (Arixtra)

Question 8

Fondaparinux metabolism

Answer 8

Renal (Arixtra)

Question 9

Fondaparinux reversal

Answer 9

None (Arixtra)

Question 10

Warfarin mechanism

Answer 10

Vit K antagonist prevents synthesis of 10,9,7,2 C, S

Question 11

Warfarin reversal

Answer 11

Vit K, FFP

Question 12

Aspirin mechansim

Answer 12

Irrev binds/inactivates COS, blocking production thromboxane A2 (prostaglandin for plt aggregation)

Question 13

Aspirin reversal

Answer 13

Plts

Question 14

Rivaroxaban mechanism

Answer 14

Xa inhib

Question 15

Rivaroxaban metabolism

Answer 15

Hepatic

Question 16

Rivaroxaban reversal

Answer 16

None

Question 17

Aspirin metabolism

Answer 17

Hepatic

Question 18

Heparin risks

Answer 18

HIT, bleeding

Question 19

LMWH risks

Answer 19

bleeding

Question 20

Fondaparinux risks

Answer 20

Highest bleeding risks

Question 21

Warfarin risks

Answer 21

adverse rxns with rifampin, phenobarbital, diuretics, cholestyramine

Question 22

Dabigatran mechanism

Answer 22

Reversible IIa inhibitor

Question 23

Dabigatran metabolism

Answer 23

renal

Question 24

Dabigatran antidote

Answer 24

Idarucizumab

Question 25

Dabigatran risks

Answer 25

GI upset, bleeding

Question 26

TXA mechanism

Answer 26

Compet inhib plasminogen by binding lysine binding site

Question 27

TXA risks

Answer 27

not associ with increased VTE