Anticoagulants Flashcards
1
Q
Heparin mechanism
A
Binds ATIII inhibiting thrombin(IIa) and Xa
2
Q
Heparin metabolism
A
Hepatic
3
Q
Heparin reversal
A
Protamine sulfate
4
Q
LMWH mechanism
A
Binds both ATIII and thrombin –> greater Xa than IIa (thrombin) inhib
5
Q
LMWH metabolism
A
Rental
6
Q
LMWH reversal
A
Protamine sulfate (partial)
7
Q
Fondaparinux mechanism
A
Xa indirect inhib (Arixtra)
8
Q
Fondaparinux metabolism
A
Renal (Arixtra)
9
Q
Fondaparinux reversal
A
None (Arixtra)
10
Q
Warfarin mechanism
A
Vit K antagonist prevents synthesis of 10,9,7,2 C, S
11
Q
Warfarin reversal
A
Vit K, FFP
12
Q
Aspirin mechansim
A
Irrev binds/inactivates COS, blocking production thromboxane A2 (prostaglandin for plt aggregation)
13
Q
Aspirin reversal
A
Plts
14
Q
Rivaroxaban mechanism
A
Xa inhib
15
Q
Rivaroxaban metabolism
A
Hepatic
