Anticoagulants Flashcards
MOA Heparin & low molecular weight heparin
enoxaparin, Lovenox
Prevents clotting by activating Antithrombin- indirectly inactivates thrombin & factor Xa
Side Effects of ALL anticoagulants
BLEEDING
Nursing Considerations of Heparin
Starts working Quickly
Adverse effects of Heparin
Bleeding, hematoma, anemia, thrombocytopenia
Indications of Enoxaparin (Lovenox)
given prophylaxis & treatment
Adverse Effects of Enoxaparin (Lovenox)
bleeding, thrombocytopenia
can cause HIT
MOA of Warfarin (Coumadin)
prevents the synthesis of four coagulation factors
VII, IX, X, prothrombin
Adverse Effects of Warfarin (Coumadin)
bleeding, lethargy, muscle pain, purple toes
MOA of Apixaban (Eliquis) & Rivaroxabean (Xarelto)
direct inhibitor of factor Xa
Adverse effects of Apixaban (Eliquis) & Rivaroxabean (Xarelto)
bleeding, hematoma, dizziness, rash, gastrointestinal distress, peripheral edema
Aspirin (as anti-platelet)
blocks prostaglandin synthesis through the COX enzyme pathways
Side effects of Aspirin
n/v, drowsiness/confusion, bleeding
MOA of Clopidogrel (Plavix) & Ticagrelor (Brilinta)
antiplatelet ADP inhibitor
Side effects of Clopidogrel & Ticagrelor
chest pain, edema, flu-like symptoms, abdominal pain, diarrhea, nausea, epistaxis, rash, pruritus
Thrombin Inhibitors
inhibit thrombin (factor lla)