Anticoagulant therapy Flashcards
1
Q
enoxaparin
indication route/onset duration of tx labs adverse effects antidote action
A
Lovenox
prophylaxis and treatment of DVT SQ, unknown lasts 12 hrs, short no labs look out for bleeding, HIT antidote protamine sulfate strengthens antithrombin action
2
Q
heparin
indication route/onset duration of tx labs therapeutic level adverse effects antidote action
A
treatment of thromboembolic (DVT, PE), prevents new but no effect on existing clots
SQ 20-60 mins, IV immediately
PTT (norm: 28-35 secs)
PTT 1.5-2.5 x normal values
look out for bleeding, HIT
protamine sulfate
enhances antithrombin III and prevents new clot formation
3
Q
warfarin
indication route/onset duration of tx labs therapeutic level adverse effects antidote action
A
Coumadin
prophylaxis and treatment of thromboembolic (DVT, PE), prevents stroke in a-fib or cardiac valve replacement PO and lasts 2-5 days PT (norm: 11-15 secs), INR (1) PT 1.5-2 x normal value, INR 2-3 vitamin K interferes with clotting factors
4
Q
Critical values of prothrombin time and partial thromboplastin time
A
PT above 30 secs
PTT above 100 secs
