Anticoagulant, Antiplatelet, and Thrombolytic Drugs

Question 1

Anticoagulants

Answer 1

-Reduce the formation of fibrin-involved in clot formation.

Question 2

Anticoagulation mechanism of action

Answer 2

-Inhibit the synthesis of clotting factors.
-Inhibit the activity of clotting factors.

Question 3

Heparin

Answer 3

-Very popular
-Enhances antithrombin
-Rapid-acting anticoagulant

Question 4

Heparin administration

Answer 4

-Administered by injection only
-IV
-Continuous infusion
-Deep subQ
-Cannot be given PO because it cannot be absorbed.

Question 5

Heparin therapeutic uses

Answer 5

-Preferred anticoagulation during pregnancy and when rapid anticoagulation is required.
-Pulmonary embolism (PE)
-Stroke evolving
-Massive DVT
-Open heart surgery
-Renal dialysis- keeps clots from forming. Can be run through equipment.
-Low dose therapy postoperatively
-Disseminated intravascular coagulation
-Adjunct to thrombolytic therapy.