Anticholinergics Flashcards
What is atropine?
Which receptors is it selective for?
What is its effect on the receptor?
Is it able to cross the BBB?
nonselective mAChR antagonist
*prototype antimuscarinic
tertiary amine/uncharged, able to cross BBB
What is benztropamine?
Which receptors is it selective for?
What is its effect on the receptor?
Is it able to cross the BBB?
M1 selective mAChR antagonist
tertiary amine/uncharged, able to cross BBB
What is trihexyphenidyl?
Which receptors is it selective for?
What is its effect on the receptor?
Is it able to cross the BBB?
M<strong>1</strong> selective mAChR antagonist
tertiary amine/uncharged, able to cross BBB
*antiparkinsonian
What is hyoscyamine?
Which receptors is it selective for?
What is its effect on the receptor?
Is it able to cross the BBB?
nonselective mAChR antagonist
tertiary amine/uncharged, able to cross BBB
What is dicyclomine?
Which receptors is it selective for?
What is its effect on the receptor?
Is it able to cross the BBB?
nonselective mAChR antagonist
tertiary amine/uncharged, able to cross BBB
*antispasmodic
What is scopolamine?
Which receptors is it selective for?
What is its effect on the receptor?
Is it able to cross the BBB?
nonselective mAChR antagonist
tertiary amine/uncharged, able to cross BBB
*motion sickness
What is ipratropium?
Which receptors is it selective for?
What is its effect on the receptor?
Is it able to cross the BBB?
nonselective mAChR antagonist
quaternary amine/charged, unable to cross BBB
What is tiotropium?
Which receptors is it selective for?
What is its effect on the receptor?
Is it able to cross the BBB?
nonselective mAChR antagonist
quaternary amine/charged, unable to cross BBB
*long half-life
What is glycopyrrolate?
Which receptors is it selective for?
What is its effect on the receptor?
Is it able to cross the BBB?
nonselective mAChR antagonist
quaternary amine/charged, unable to cross BBB
What is oxybutynin?
Which receptors is it selective for?
What is its effect on the receptor?
Is it able to cross the BBB?
partially selective M3 mAChR antagonist
quaternary amine/charged, unable to cross BBB
What is tolterodine?
Which receptors is it selective for?
What is its effect on the receptor?
Is it able to cross the BBB?
selective M3 mAChR antagonist
quaternary amine/charged, unable to cross BBB
*overactive bladder
What is darfenacin?
Which receptors is it selective for?
What is its effect on the receptor?
Is it able to cross the BBB?
selective M3 mAChR antagonist
quaternary amine/charged, unable to cross BBB
What is solifenacin?
Which receptors is it selective for?
What is its effect on the receptor?
Is it able to cross the BBB?
selective M3 mAChR antagonist
quaternary amine/charged, unable to cross BBB
*overactive bladder
What anticholinergics would be most effective in treating motion sickness?
-scopolamine
*tertiary, able to cross BBB
What anticholinergics would be most effective in treating diarrhea/GI hypermotility?
-atropine
Antispasmotics:
- glycopyrrolate
- dicyclomine
- hyoscyamine