Anticholinergics

Question 0

Anticholinergic is used interchangeably with with what other term?

Answer 0

-Antimuscarinic

Though anticholinergics have effects at Nicotinic cholinergic sites, as well

Question 1

Function of anticholinergic drugs

Answer 1

• Competitively antagonize effects of Ach

- Can be naturally occuring or synthetic agents

Question 2

Drugs we used are considered ________at usual doses

Answer 2

antimuscarinic

Question 3

If naturally occurring, anticholinergics are______ from the ______plant

Answer 3

• alkaloids

- Belladonna plant

Question 4

Synthetic anticholinergics are this type of derivative

Answer 4

quaternary ammonium derivatives

Question 5

Naturally occuring are______from the combination of tropic acid and a complex organic base, the drugs are _____forms

Answer 5

• esters

- racemic

Question 6

These drug classes have similar structures to anticholinergic drugs and therefor have some Antimuscarinic effects

Answer 6

• antihistamines
• antipsychotics
• antidepressants

Question 7

Anticholinergic MOA

Answer 7

• Combines reversibly with receptor (prevent Ach from activating site)
• Effects overcome by increasing Ach concentrations
• Effects of muscarinic action due to 5 subsets of muscarinic receptors

Question 8

Where are the 5 subsets of Muscarinic actions located? M1, M2,M3, M4, and M5 receptors

Answer 8

• M1: CNS & stomach
• M2: CNS,airway smooth muscle, heart
• M3: CNS, Glands, airway smooth muscle
• M4: CNS, Heart
• M5: CNS

Question 9

Effect of lower doses on M3 (glands-bronchial and salivary)

Answer 9

-receptors inhibited @ lower doses

Question 10

Effect of slightly higher doses @ M1&M2 receptors

Answer 10

• M1: higher doses will inhibit M1 cholinergic control of GI motility, secretions, and urination
• M2, Heart & eye stimulated

Question 11

Receptor site offset by anticholinergics

Answer 11

Only muscarinic (Not nicotinic)