AntiCancer Med Chem

Question 1

Cytotoxic Anticancer classes

Answer 1

Alkylating agents
antimetabolites
anti-microtubule agents
DNA Binders

Question 2

Targeted Therapy Classes

Answer 2

• Hormones and Hormone Antagonists (ER and AR signalling)
• Antibody and Antibody-Drug Conjugates(ADC)
• Kinase Inhibitors

Question 3

Why do cancer chemotherapy drugs have many GI system SE?

Answer 3

Because they attack quickly divinding cells. GI cells divide quickly and therefore give you your GI effects. (N/V)

Question 4

Alkylating Agents

Answer 4

• Nitrogen Mustards: Cyclophosphamide
• Platinum Derivatives: Cisplatin
• Triazenes: Temozolomide

Question 5

What is the general MOA for Alkylating agents?

Answer 5

-They permanently attach to the DNA, disrupt DNA structure and function.

Question 6

How does resistance to Alkylating agents occur?

Answer 6

-Alkylating agents binds to DNA, is seen as damage, and is killed. If DNA repair enzymes are able to correct the lesions prior to cell division, the effect of the alkylating agent can be negated and resistance develops. If the damage is too much to be repaired, p53 starts apoptosis. Mutations in this gene can lead to resistance as well. due to failure to undergo apoptosis

Question 7

What is an example of a Nitrogen Mustard

Answer 7

-Cyclophosphamide