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Pharmacology > Anticancer drugs > Flashcards

Anticancer drugs Flashcards

1
Q

Doc Head and neck tumor

A

Cisplatin

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2
Q

bladder cancer regimen

A

cisplatin + gemcitabine

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3
Q

small cell cancer (toc)

A

cisplatin + etoposide

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4
Q

DOC for esophageal and gastric cancer

A

Cisplatin

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5
Q

bivalent and quad platinum compounds

A

cisplatin carboplatin
oxaliplatin

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6
Q

Dose limiting side effect of 5FU

A

Peripheral neuropathy

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7
Q

ovarian cancer

A

cis+taxanes

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8
Q

squamous cell cancer

A

gemcitabine+ cis+ eto+ vinorelbine

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9
Q

Why is oxaliplatin used with 5FU

A

Blocks thymidylate synthase
Used in colorectal cancer

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10
Q

non scc

A

cis+eto+vinorelbine+pamitrexed

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11
Q

testicular cancer regimen

A

BEP bleomycin +etoposide+ plat

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12
Q

regimen for CR cancer

A

folfox folfirinox
folfiri

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13
Q

Dose limiting toxicity of carboplatin

A

BM supression

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14
Q

DOC Brain tumor

A

tenozolamide

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15
Q

doc for colorectal and anal cancer

A

5 flurouracil

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16
Q

cisplatin side effects

A

severe NV (doc)
ototoxic
peripheral neuropathy
coasting effect
nephrotoxic (potent)
raynauds

Preload patient with 2L of normal saline
Cl- diuresis causes inactivation of cisplatin + mannitol ( forced diuresis)+ amifostine (radioprotective drug)
4 drug regimen for severe nausea vomiting (doc - ondonsetron)

17
Q

prostate cancer

A

GnRH agonist - Goserelin

18
Q

cisplatin is doc for?

A

head and neck
brain
urogenital
gastric and oesophageal
osteosacoma
lung cancer

19
Q

MOA of bleomycin

A

inhibits topoisomerase 2 s phase
free radical damage g2 phase

not cell cycle specific

20
Q

Which is cell cycle specific
bleo or plat?

A

Bleomycin is relatively cell cycle specific

If bleomycin is given in the option with specific phase eg M phase inhibitor then bleo is non specifc

21
Q

SIDE EFFECTS OF BLEOMYCIN

A

PULMONARY FIBROSIS
FLAGELLATE DERMATITIS

22
Q

Uses of bleomycin

A

AML
Hodgkins ABVD
Testicular BEP

23
Q
A

Pharmacology (4 decks)

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