Anticancer Drugs Flashcards by Seb Muk | Brainscape

Q

What is Cis Platin?

A

Square planar molecule.

2 Cl top and bottom left, Pt in middle, 2 NH3 top and bottom right

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Q

How does cis platin work?

A

Cis platin binds to nitrogen atoms on bases of DNA
Cis Platin passes through cell membrane undergoing ligand exchange (Cl replaced by H2O)
Nitrogen better ligand than water so forms dative covalent bonds with cis platin
Cis platin distorts shape of DNA and prevents it from replicating

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Q

Effects of using Cis Platin against cancer?

A

Binds to healthy cells too (hair loss)
But affects cancer cells more
Balance needs to be accepted by society, because it is very effective, news therapeutic pathways on the way

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