Antibodies high yield

Question 1

anti-centromere pattern of ANA

Answer 1

CREST (calcinosis, Raynaud, esophageal dysmotility, sclerodactyly, telangiectasis)
Limited cutaneous systemic sclerosis

Question 2

anti-DS DNA

Answer 2

SLE, typically more severed disease with renal involvement, can also follow for disease activity

Question 3

anti-Smith

Answer 3

most specific test for SLE

Question 4

anti-U1-RNP

Answer 4

mixed connective tissue disease (especially high titers >1:10,000)
can also be positive in SLE

Question 5

anti-smooth muscle antibody

Answer 5

autoimmune hepatitis BUT can also be in primary sclerosing cholangitis

Question 6

anti-Ro/SSA antibody

Answer 6

Sjogren syndrome, neonatal SLE (rash and heart block), subacute cutaneous lupus, SLE as well

Question 7

anti-La/SSB antibody

Answer 7

Sjogren syndrome, neonatal SLE (rash and heart block)

Question 8

anti-SCL-70

Answer 8

aka anti-topoisomerase

diffuse cutaneous systemic sclerosis with increased risk for pulmonary fibrosis

Question 9

anti-centromere

Answer 9

CREST
Limited cutaneous systemic sclerosis
increased risk for pulmonary HTN

Question 10

c-ANCA

Answer 10

aka antiproteinase-3

granulomatosis with polyangiitis (formerly Wegener): upper respiratory tract, lungs, kidneys

Question 11

p-ANCA

Answer 11

aka antimyeloperoxidase
microscopic polyangitis: lungs, kidneys
eosinophilic granulomatosis with polyangiitis (formerly Churg Strauss): preceding atopy, lung disease, mononeuritis multiplex or mono- or poly-neuropathy. *40% of pts w eosinophilic granulomaosis with polyangiitis are ANCA negative so negative ANCA does not rule out

Question 12

anti-Jo-1 antibody

Answer 12

polymyositis
increased risk for antisynthetase syndrome (acute onset, constitutional syndromes, Raynaud’s, mechanic’s (hyperkeratotic) hands, arthtritis, interstitial lung disease

Question 13

rheumatoid factor

Answer 13

RA, Sjogren, cryoglobulinemia

also can be + in endocarditis

Question 14

anti-CCP

Answer 14

RA, associated with erosions and disease progression

Question 15

anti-histone

Answer 15

drug induced lupus erythematosis, also seen in regular SLE

Question 16

cryoglobulins

Answer 16

vasculitis
hepatitis C
myeloma
SLE
RA

Question 17

anti-mitochondrial antibodies

Answer 17

primary biliary cirrhosis

autoimmune hepatitis