Antibodies and Antigens Flashcards
1
Q
IgM
A
- μ heavy chain
- B-cell recepter
- Activates Complement
- Monomer on B-cell
- Pentamer found in serum
- Present in blood and heart
- blood born infections
- 1st Ab produced
- half life is approx 5 days
2
Q
IgD
A
- δ heavy chain
- Very labile (degraded immediately inblood so only fxn as receptor on surface of B-cell)
- B-cell receptor
- Monomer
- Marker for mature B cell
- Very low concentration in serum because as soon as it is made and released into the serum, it is degraded bc it is unstable
3
Q
IgG 1-4
A
- γ heavy chain
- Activates complement
- Crosses placenta; Provides immunity in developing fetus
- Present in all tissues
- longest half life–20-23 days (therefore, highest concentration in serum)
- Provides passive immunity because of long half life
- monomer
4
Q
IgA
A
- α heavy chain
- Protects mucosal surfaces
- Monomer in serum/blood
- Dimer in secretions at mucosal surfaces (Secretory component associated with the dimeric form)
- Dimeric; found in secretions: GI, urogenital, respiratory, breast milk, protecets against foreign pathogens
5
Q
IgE
A
- ε heavy chain
- Anti-parasitic; important protective fxn
- Mediates allergic rxns
- Immediately binds mast cells in CT once secreted so not found free floating
- Found in blood vessels
- LOWEST serum concentration
- SHORTEST half life
