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Antibodies > Antibodies > Flashcards

Antibodies Flashcards

1
Q

Limited Cutaneous Systemic Sclerosis

A

Anti-centromere (an ANA)

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2
Q

Systemic Cutaneous Systemic Sclerosis

A

Anti-topoisomerase (an ANA)

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3
Q

CREST syndrome

A 
Anti-centromere (an ANA)
CREST syndrome = Limited Cutaenous Systemic Sclerosis
C - calcinosis
R - raynauds
E - oesophageal dysmotility
S - sclerodactyly
T - telangectasia
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4
Q

Systemic Vasculitis

Group of conditions

A

Anti-neutrophil cytoplasmic antibody (ANCA)

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5
Q

Granulomatosis with polyangiitis (GPA)

Wegener’s Granolomatosis

A

Cytoplasmic ANCA (cANCA)

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6
Q

Eosinophilic Granlomatosis with Polyangiitis

Churg-Strauss Syndrome

A

Perinuclear ANCA (pANCA)

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7
Q

Microscopic Polyangiitis

A

Perinuclear ANCA (pANCA)

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8
Q

Ulcerative Colitis

A

Perinuclear ANCA (pANCA) - specific but not sensitive

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9
Q

Primary Sclerosing Cholangitis

A

Perinuclear ANCA (pANCA)

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10
Q

Rheumatoid Arthritis

A

Rheumatoid Factor = IgM anti-IgG antibody (Type III reaction)
Anti-cyclic citrullinated peptide antibody (Type II reaction)
pANCA

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11
Q

Systemic Lupus Erythematosus

A

Anti-double stranded DNA (anti-dsDNA) (an ANA) - specific

Anti-Sm (an anti-ENA)

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12
Q

Sjögren’s Syndrome

A

Anti-extractable nuclear antigens (anti-ENA):
Anti-ro
Anti-la

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13
Q

Scleroderma

A

Anti-Scl70 (an anti-ENA)

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14
Q

Dermatomyositis

A

Anti-Jo-1 (an ENA and type of anti-tRNA synthetase)

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15
Q

Anti-phopholipid Syndrome

A

Anti-cardiolipin (an anti-mitochondrial antibody_

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16
Q

Autoimmune Hepatitis

A

Anti-smoothh muscle antibody
Anti-Liver Kidney microsomal-1 (anti-LKM-1)
Anti-soluble liver antigen )anti-SLA)

17
Q

Autoimmune Haemolytic Anaemia (in pregnancy)

A

Anti-Rh

18
Q

Coeliac Disease

A

Anti-tissue transglutaminase antibody (anti-TTG)

Anti-endomysial antibody

19
Q

Dermatitis Herpetiformis

A

Anti-endomysial antibody

20
Q

Goodpasture’s Syndrome

A

Anti-glomerula basement membrane antibody (anti-GBM)

21
Q

Grave’s disease

A

Anti-thyroid stimulating hormone receptor antibody (anti-TSHR)

22
Q

Hashimoto’s Thyroiditis

Autoimmune hypothryroidism

A

Anti-thyroglobulin (T4) and anti-thyroperoxidase (T3) antibodies (anti-thyroid hormone)

23
Q

Myaesthenia Gravis

A

Anti-acetylcholine receptor antibody (anti-AchR)

24
Q

Pernicious Anaemia

A

Gastric parietal cell antibody (90%)

Intrinsic factor antibody (50%)

25
Q

Polymyositis

A

Anti-Jo-1 (an anti-ENA and anti-tRNA synthetase)

26
Q

Primary Biliary Cirrhosis

A

Anti-mitochondrial antibody

27
Q

Type 1 Diabetes Mellitus

A

Pancreatic beta-cell antibody

Glutamate decarboxylase antibody

28
Q

Type 2 Membranoproliferative Glomerulonephritis

A

C3 Nephritic Factor (anti-IgG antibody)

Antibodies (1 decks)

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