Antibodies

Question 1

ANA

Answer 1

antinuclear antibodies 
screening test for CTD 
highly sensitive for SLE 
also present in normal population 
negative ANA excludes SLE

Question 2

ANCA and the two types

Answer 2

small vessel vasculitis
p-ANCA: microscopic polyangitis, EPGA (Eosinophilic Granulomatosis with Polyangiitis)
c-ANCA: GPA = granulomatosis with polyangitis

Question 3

Sjorgens

Answer 3

Ro (anti SSA) and La (anti SSB)

can also be raised in subacute SLE

Question 4

Anti-CCP

Answer 4

rheumatoid arthritis

Question 5

ENA

Answer 5

umbrella term for specific connective tissues antibodies

Question 6

Rheumatoid arthritis antibodies?

Answer 6

Anti-CCP, Rheumatoid factor

Question 7

Lupus

Answer 7

dsDNA - double stranded DNA, antibody test for SLE often raised when disease is active
Anti-Sm
nRNP

Question 8

antiphospholipid antibodies

Answer 8

lupus anticoagulant testing

caridolipin antibodies

Question 9

low complement levels - C3 and C4

Answer 9

SLE

Question 10

ankolysing spondylitis

Answer 10

HLA-B27 (90%)

Question 11

limited cutaneous systemic sclerosis - CREST

Answer 11

anti-centromere

Question 12

myositis

Answer 12

anti-SRP

Question 13

dermatomyositis

Answer 13

Jo-1

Question 14

mixed connective tissue disease - MCTD

Answer 14

nRNP

Question 15

progressive/diffuse cutaneous systemic sclerosis

Answer 15

Anti SCL-70