Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Rheum > Antibodies > Flashcards

Antibodies Flashcards

1
Q

ANA pattern in SLE

A

Homogenous

(dsDNA, DNA histone)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

ANA pattern in dSSC

A

Nucleolar

(bomb)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

ANA pattern in lSSc

A

Centromere

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

ANA pattern in SS

A

Diffuse speckled

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Diseases w/ homogenous ANA

A

SLE
(RA 20%)
Abs targeting DNA & histones

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Diseases w/ speckled ANA

A

Abs to ENA
Any - can be healthy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Diseases w/ nucleolar ANA

A

dSSc

(RNA polymerase, Scl-70)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Diseases w/ centromere ANA

A

lSSc

(Abs along c/s)
PBC & other odd AI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

ANA pattern in RA

A

Speckled, homogenous

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Homogenous staining pattern results from which Abs

A

DNA & histones

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Speckled staining pattern results from which Abs

A

ENA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Antisynthetase Abs - types & implications

A

Jo-1, (PL-7, PL-12)

Assoc w/ ILD (UIP)
DM rash also common: mechanics, heliotrope rash etc
Some can be amyopathy - but otherwise proximal myopathy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Malignancy assoc Abs in IDIM

A

TIF-Y (gamma)
NXP2
(MDA5 is ILD & melanoma)
If >40 LOOK FOR CaNCER!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

IMNM Abs

A

HMGCR
Anti SRP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

DM Abs

A

Malignancy assoc: TiF-Y, NXP2
Mi2 classic/mild
MDA5: ILD rapid, can be amyopathic, classic DC rash, bad

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

IBM

A

cN1A - weakness, assoc w/ bulbar
Insidious
Dysphagia common
Assoc w/ other AI dis

17
Q

Overlap IMIN Abs

A

Ro52 - SS? most common non spec, ILD
PM-SCL - SSc (skin & lung)
U1RNP - mixed CTD
Anti Ku - SSc

18
Q

Muscle bx in IDIM types

A
  • DerM: capillaries (vasculitis), perifasicular myofibre atrophy, keratinocytes
  • PM: diffuse mm fibre injury, CD8 invade myofibres, MHC Class I
  • IMNM: myofibral necrosis w/ no inflammation (no immune cell invasion of myofibres ie Ø lymphocytic infiltrates)
  • Antisynthetase syndrome: perifasicular necrosis, perimysium fragmentation & ↑ perimysial ALP activity
  • IBM:more like PM
19
Q

RA - genetic assoc

A

HLA-DRB1

esp if ACPA+ (anti-CCP)

20
Q

dSSc Abs

A

Anti-Scl 70 (ENA)
- assoc w/ ILD

Anti-RNA polymerase
- assoc w/ SRC

21
Q

lSSC Abs

A

Anti-centromere

22
Q

PBC Abs

A

AMA - anti mitochondrial Abs

23
Q

SLE dx

A
  • ANA 1:80 (speckled)
  • anti-dsDNA (specific)
  • anti-Smith (renal & CNS dis specific)
  • APLS (LAC, antiCardiolipin, beta2)
  • Low C’ - predicts flares w. Abs
24
Q

Seroneg arthritis

A
  • Ank Spond
  • OA
  • PsA
  • Infectious - gonoccocal, septic
  • Gout/pseudogout
  • Haemaochromatosis
25
Q

Seropositive arthritis & markers

A
  • Lupus: ANA, ENA, (RF) - no erosions on XR
  • Reactive: HLAB27+
  • RA: RF+, CCP+
  • Sjogrens

Rheum (5 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions