Antibiotics used in GC/Ct infections/STIs

Question 1

Quinolones

Levofloxacin, Ofloxacin

Answer 1

MOA: xDNA Gyrase

AEs: taste disturbance, GI upset, Cat C for pregnancy

BBW: inc risk TENDONITIS and rupture
BBW: inc risk muscle weakness - avoid w/ myasthenia gravis

Question 2

Rifampin

Answer 2

MOA: xRNA polymerase

AEs: red secretions, liver dysfunction, don’t take w/ aluminum sulfate/antacids, …

Question 3

Aminoglycosides

Streptomycin and Gentamicin

Answer 3

MOA: x30s Ribosomal initiation complex

AEs:

Question 4

Macrolide

Erythromycin and Azithromycin

Answer 4

MOA: xtRNA/peptide elongation
* Cat B for pregnancy - hypertrophic pyloric stenosis in newborn

AEs: Gi upset, vaginitis
erythro = cyp3A4 and P-gp substrate

Question 5

Metronidazole/Tinidazole: MOA, uses, AEs

Answer 5

MOA: unionized drug taken up by anaerobic organisms and cells –> reduced to active form –> disrupts DNA helical structure

Uses: trichomoniasis or BV or Cervicitis (recurrent)

AE: xIn pregnancy or breastfeeding, GI upset, candidiasis,