Antibiotics, Toxins

Question 1

Alpha amanitine - from what and inhibits what?

Answer 1

mushrooms; RNA polymerase II - transcription

Question 2

RIcin

Answer 2

castor oil; inactivates 60s ribosome - translation

Question 3

Diphtheria toxin

Answer 3

catalyze ADP ribosylation and inactivation of EF-2 - Elongation of bacterial translation

Question 4

Trichothecen mycotoxins

Answer 4

molds/fungi; inhibit ribosomal activity - translation

Question 5

Quinolones (nalidixic acid, ciprofloxacin)

Answer 5

bacterial topoisomerase inhibitor (bacterial gyrase)

Question 6

Aminocoumarins (novobiocin)

Answer 6

bacterial topoisomerase inhibitor (bacterial gyrase)

Question 7

Daunorubicin, doxorubicin

Answer 7

intercalcate eukaryotic topoisomerase - transcription

Question 8

etoposide

Answer 8

inhibit mammalian topoisomerase - transcription

Question 9

Penicillin, Methicillin, Oxacillin, flucloxacillin, dicloxacillin

Answer 9

bacterial wall synthesis inhibitors

Question 10

cisplatin

Answer 10

metal therapeutics that bind nucleotide bases - transcription

Question 11

streptomycin

Answer 11

binds and distorts 30s ribosome - Initiation of bacterial translation

Question 12

tetracyclines

Answer 12

block aminoacyl-tRNA to A site by interacting with bacterial 30s ribosome - Elongation of translation

Question 13

puromycin

Answer 13

similar to aminoacyl-tRNA and blocks peptide chain growht - Elongation of eukaryotic and bacterial translation

Question 14

chloramphenicol

Answer 14

inhibits prokaryotic peptidyltransfease - elongation of bacterial translation

Question 15

clindamycin and erythromycin

Answer 15

bind 50s subunit ribosome and inhibits translocation - elongation of bacterial translation