Antibiotics specific to bacteria Flashcards
Penicillin - bacteriostatic/bactericidal - excreted via liver/kidney
Bacteriostatic - autolysis of bacterial cell wall
Excreted via kidneys
Penicillin for Grm +ve
Floxacillin (IV/oral)
Used for Staph/Strep
Penicillin for Grm -ve
Temocillin (IV)
B-lactamase resistant
Used against coliforms
Penicillin for Grm +ve / -ve
Amoxicillin - susceptible to b-lactamase
Co-amoxiclav - effective against anything except - Pseudomonas/ MRSA.
Piperacillin / Tazobactam - beta-lactamase inhibitor & effective against psudemonous / MRSA.
Cephalosporins prevent what?
Cross-linage of the peptidoglycan
Glycopeptide
vancomycin- IV effective than oral (Grm+ve - Clostridium, Step, enterobacteria, Staph, MRSA
Teicoplanin (against grm -ve)
Metronidazole (Strict Anaerobes)
Clostridium + Bacteriods
Quinolones - bacteriostatic/bactericidal - excretion via urine /liver
Ciprofloxacin & Levofloxacin
Bactericidal - excretion via urine
Used to treat psudemonous
Cephalosporin excreted via Liver/Kidney
via kidney
Cephalosporin - bad why?
Effects gut flora
Glycopeptide target
bind to the of the growing pentapeptide chain = autolysis
Cephalosporin antibiotic generations
1st - cefalexin - UTI
2nd - cefuroxime - used little
3rd - cefixime (Neisseria. spp) / ceftazidime (pseudomonas)
Macrolides targets
blocks translocation of protein synthesis
Macrolides - bacterial treatments
used to treat intracellular organisms - legionella OR bacteria without walls e.g. chlamydia/mycoplasma
Aminoglycosides
Gentamicin - active against coliform, pseudomonas
