Antibiotics SE

Question 1

SE of aminoglycosides

Answer 1

Neuromuscular blockage → respiratory paralysis
Nephrotoxicity
Ototoxicity

Question 2

Patient groups require caution use of aminoglycosides

Answer 2

Caution in myasthenia gravis & parkinsonism

Question 3

Toxicity of tazocin is forgot renal adj

Answer 3

Seizure (in pt with seizure)

Thrombocytopenia / Leukopenia / Neutropenia

Question 4

SE of cefuroxime & ceftriaxone

Answer 4

Increase INR

Question 5

DDI of linezolid

Answer 5

Serotonin syndrome

- tramadol, codeine, Dextromethorphan, MOAIs, SSRI, bupropion, carbamazepine

Question 6

DDI of ertapenem & imipenem

Answer 6

Valproate –> worsen seizure control

Question 7

Age limit of Doxycycline / Tetracycline

Answer 7

≥8 years use

Question 8

Age limit of Levofloxacin

Answer 8

> 6mo

Question 9

SE of tetracycline

Answer 9

Tooth discolouration (due to binding to Ca2+)
Bone deformities (due to binding to Ca2+)
Photosensitivity → skin rash
Renal & hepatic toxicity @high dose
Superinfection (Intestine, vagina)

Question 10

SE of quinolone

Answer 10

1. Photosensitivity
2. tendonitis / tendon rupture
3. Peripheral neuropathy

Question 11

SE of daptomycin

Answer 11

Myopathy and rhabdomyolysis especially in patients taking statins