Antibiotics & Other Antimicrobials Flashcards
What are the indications for tetracyclines in dermatology?
Acne, rosacea, HS, dissecting cellulitis, lichen planus, pityriasis lichenoides
Neutrophilic dermatoses
Autoimmune bullous diseases
CARP/ Prurigo pigmentosa
Granulomatous disorders
Syphilis
Atypical mycobacteria
Rickettsial disease
What are the contraindications to tetracyclines?
Hypersensitivity
Pregnancy/lactation
Children <9 years
Renal impairment (minocycline)
Hepatic impairment (doxycycline)
What are the adverse effects of tetracyclines?
GI effects, benign intracranial hypertension, photosensitivity, candidiasis, anaphylaxis
Minocycline specific
Dyspigmentation, vertigo, SJS/TEN, DRESS, lupus, vasculitis
Hepatitis, immune thrombocytopenia
What baseline and ongoing monitoring is required for tetracyclines?
Baseline and every 4-6 months
FBC, UEC, LFT, ANA
What are the dermatologic indications for erythromycin?
Acne, rosacea
Pityriasis lichenoides
CARP/Prurigo pigmentosa
Erythrasma
Erythema annulare centrifugum
Skin infections
What are the contraindications for erythromycin?
Hypersensitivity
What pregnancy category is erythromycin?
Category A
What drugs interact with erythromycin ?
QT prolonging drugs
CYP 1A2
CYP 3A4
What are the adverse effects of erythromycin?
GI effects
Hypersensitivity
Hearing loss
Dysrhythmias/QT prolongation
Hepatitis
What is the standard weight based dosing for ivermectin?
200mcg/kg
What are the contraindications to ivermectin?
Hypersensitivity
Pregnancy/lactation
<15kg body weight
Latex allergy
Helminth infestation
What are the adverse effects of ivermectin?
Common: pruritus, GI effects, fever, lymphadenopathy, Mazotti type reaction
Serious: hypersensitivity reaction, SJS, tachycardia, hypotension, hepatitis
