Antibiotics need to know - 1st year

Question 1

CAP 0-2 on CURB-65

Answer 1

Amoxicillin

Question 2

CAP 0-2 CURB-65 allergic to penicillin

Answer 2

Doxycycline

Question 3

CAP 3-5 CURB-65

Answer 3

Co-amoxiclav and clarithromycin both IV or Co-amoxiclav IV and doxycline PO

Question 4

CAP 3-5 CURB-65 allergic to penicillin

Answer 4

IV Levofloxacin

Question 5

Non-severe HAP

Answer 5

PO amoxicillin and metrondiazole

Question 6

Severe HAP

Answer 6

IV amoxicillin, metrondiazole and gentamicin –> step down to PO co-trimoxazole and metronidazole

Question 7

Allergic to penicillin for non-severe and severe HAP

Answer 7

IV co-trimoxazole, metronidazole +/- gentamicin –> step down to PO co-trimoxazole and metronidazole

Question 8

Acute exacerbation of COPD

Answer 8

Amoxicillin (2nd line doxycycline) - if no sputum purulence, no antibiotics unless consolidation on CXR or signs of pneumonia

Question 9

Native valve indolent (subacute) endocarditis

Answer 9

amoxicillin IV and gentamicin

Question 10

Native valve severe sepsis endocarditis

Answer 10

Flucloxacillin - this form is common with IVDU

Question 11

Prosthetic valve or suspected MRSA endocarditis

Answer 11

Vancomycin IV, rifampicin PO and gentamicin IV

Question 12

Native valve severe sepsis and risk factors for resistant pathogens

Answer 12

Vancomycin IV and meropenem IV

Question 13

C Diff. non-severe

Answer 13

metronidazole PO

Question 14

C Diff. severe

Answer 14

Vancomycin PO/NG +/- metronidazole

Question 15

Peritonitis/ biliary tract/ intra-abdominal

Answer 15

IV amoxicillin, metronidazole and gentamicin –> step down to PO co-trimoxazole and metronidazole

Question 16

Peritonitis/ biliary tract/ intra-abdominal if penicillin allergic

Answer 16

IV vancomycin, metronidazole and gentamicin –> step down to PO co-trimoxazole and metronidazole

Question 17

Proven spontaneous bacterial peritonitis – non-severe

Answer 17

co-trimoxazole PO

Question 18

Proven spontaneous bacterial peritonitis – severe

Answer 18

pipercillin/tazobactam IV then step down to co-trimoxazole PO

Question 19

Acute gastroenteritis and pancreatitis

Answer 19

Do not require antibiotics

Question 20

Campylobacteur infection

Answer 20

erythromycin or ciprofloxacin if patient develops systemic illness

Question 21

Salmonella

Answer 21

Ciprofloxacin if patient is patient is at risk or develops a systemic illness

Question 22

Shigella

Answer 22

Strains acquired from abroad require treatment with ciprofloxacin

Question 23

E-coli

Answer 23

Do not give as it may cause verotoxin (VTEC) to be released

Question 24

Typhoid/ paratyphoid fever

Answer 24

Ciprofloxacin although resistance is becoming more common - associated with salmonella

Question 25

Cholera

Answer 25

Don’t use antibiotics

Question 26

Enterobius vermicularis (threadworms)

Answer 26

Oral mebendazole

Question 27

Staph. Aureus

Answer 27

Flucloxacillin

Question 28

MRSA

Answer 28

vancomycin or teicoplarin

Question 29

Amoebiasis and giardiasis

Answer 29

Metronidazole

Question 30

Legionaire’s disease

Answer 30

erythromycin or clarithromycin

Question 31

Epiglottitis

Answer 31

ceftriaxone

Question 32

TB

Answer 32

Rifampicin, pyraziriamide, ethambutol, isoniazid (2 months)

Rifampicin and isoniazid fro a further 4 months