Antibiotics: More Flashcards
What is the activity of cefepime?
broad gram pos and gram negative activity including against enterobacter and pseudomonas
How can I recognize third generation cephalosporins?
often have t: cephotaxime, ceftriaxone, ceftazidime (though many 2nd gen cephalosporins do too)
What monobactam should I know?
aztreonam
Use of aztreonam?
aerobic gram neg rods: Pseudomonas
distributes to CNS. not cross-allergenic with other beta lactams
What are carbapenems?
beta lactams but they have different stereochemistry in the beta lactam ring so tend to be resistant to beta lactamases
broad spectrum- gram pos, most gram neg rods, anaerobes. not MRSA, C diff, legionella
Vancomycin: MoA
binds termal D-ala d alal of peptide chane. causes steric bulk that inhibits transglycosylase: not elongation of the peptidoglycan
Vancomycin: spectrum
only gram positive: too big to penetrate the outer membrane of gram negatives.
What toxicities are associated with vancomycin?
ototoxicity, nephrotoxicity, skin flushing
What is telavancin?
vancomycin derivative with a longer half life
Daptomycin: MoA
pore-forming membrane lytic molecule.
Daptomycin: activity
gram positives- including MRSA and VRSA
What toxicities are associated with daptomycin?
myopathy, allergy pnemonitis.
antagonized by interaction with pulmonary surfactant.
DON’T USE TO TREAT PNEUMONIA
