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antibiotics > Antibiotics / Microman (2018) / Microbiology Summary > Flashcards

Antibiotics / Microman (2018) / Microbiology Summary Flashcards

1
Q

If you’re looking for specific antibiotic treatments then go onto ‘The Holy Grail (Treatments)’ Brainscape subject, and see the deck ‘Infections’. This specific deck will be for general microbiological facts you need to know to understand Antibiotics. It will also cover themes of Tayside Microman 2018.

A

WANSUM?

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2
Q

Side effects of Gentamycin?

A
  • Renal damage

- Damage to CN VIII (deafness and dizziness)

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3
Q

What family of antibiotics are best known to cause erythema (redness)

A

Cephalosporins

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4
Q

Purple

Stains well due to thick peptidoglycan wall

A

Gram positive

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5
Q

Pink

Has a thin peptidoglycan wall

A

Gram negative

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6
Q

Exotoxin exported from the cell wall

A

Gram positive

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7
Q

Endotoxin is part of the cell wall

A

Gram negative

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8
Q

Gram positive chain

A

Streptococci

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9
Q

Test for Streptococci?

A

Haemolysis

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10
Q

Alpha haemolysis colour

A

Partial haemolysis: Green

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11
Q

Beta haemolysis colour

A

Complete haemolysis: Yellow/ translucent

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12
Q

Gamma haemolysis colour

A

No haemolysis: Red

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13
Q

Alpha haemolysis organisms

A

Strep pneumoniae

Strep viridans

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14
Q

Beta haemolysis organisms

A

Strep (A) pyogenes

Strep B

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15
Q

Gamma haemolysis organisms

A

Enterococcus faecalis (Strep D)

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16
Q

What diseases does Strep pyogenes most commonly cause?

A

Strep throat
Rheumatic fever
Acute glomerular nephritis
Scarlet fever

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17
Q

What diseases does Strep viridans most commonly cause?

A

Endocarditis- post dental treatment

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18
Q

What diseases does Enterococcus faecalis most commonly cause?

A

It’s a harmless commensal- but can cause intra-abdominal infections if it gets into the peritoneum.

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19
Q

What organisms usually cause bacterial meningitis in newborns

A

Strep B

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20
Q

What are the two most common organisms that cause bacterial meningitis is adults and children?

A

Neisseria meningitidis

Strep pneumoniae

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21
Q

Gram positive clusters

A

Staphlococci

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22
Q

Test for Staphlococci?

A

Coagulase test

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23
Q

Positive coagulase Staph

A

Staph Aureus

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24
Q

Negative coagulase Staph

A

Staff epidermidis

Skin commensals

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25
Q

What does Methicillin-resistant Staph Aureus (MRSA) produce?

A

Panton valentine leucocidin

This causes necrolytic skin infections

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26
Q

Gram positive bacilli (rods) organisms?

A 
Clostiridium difficile
Bacillus cereus 
Listeria monocytogenes
Saccharopolyspora rectivirgula
Others
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27
Q

What toxins does C. difficile release?

A

Enterotoxin A
Cytotoxin B
When stressed- spores that can withstand extreme conditions

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28
Q

How are the investigations for C. difficile?

A

Stool culture

Bacterial DNA/ toxin

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29
Q

What are the four antibiotics that lead to C. difficile

A

Ciprofloxacin
Co-amoxiclav
Clindamycin
Cephalosporins (Ceftriaxone)

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30
Q

How does one catch bacillus cereus?

A

From eating reheated rice

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31
Q

Gram negative cocci organisms?

A

Neisseria meningitidis
Neisseria gonorrhoeae

Both of these present as diplococci

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32
Q

Gra negative coccobacillus (half cocci, half cocci)

A

Haemophilus influenzae
Chlamydia Trochomatis
Bordetella pertussis

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33
Q

What does bordetella pertussis most commonly cause?

A

Pertussis- i.e. “whooping cough” in children

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34
Q

Gram negative bacilli (rods) organisms?

A 
Pseudomonas
Escherichia coli
Klebsiella
Shigella
Proteus (vulgaris, mirabilis, penneri)
Enterobacter
Citrobacter
Salmonella
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35
Q

What the shit type of E. coli to get?

A

E. coli 0157

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36
Q

What does E. coli 0157 produce?

A

Verotoxin (VTEC)

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37
Q

Gram negative helical shaped organisms?

A

Campylobacter

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38
Q

Want to know a fun fact about co-amoxiclav?

A

It treats basically everything apart from Pseudomonas and MRSA

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39
Q

Name some gut commensals

A

E. coli
Klebsiella
Proteus

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40
Q

Name some gut pathogens

A

E. coli 0157
Shigella
Salmonella

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41
Q

Organism associated with chest infections and pidgeons/parrots as pets

A

Chlamydophila psittaci

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42
Q

Organism associated with dry cough and diarrhoea, with a background of holiday abroad + contact with foreign water

A

Legionella pneumophila

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43
Q

Red jelly sputum

A

Klebsiella pneumoniae

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44
Q

Rusty sputum

A

Pneumococcal pneumonia

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45
Q

What’s another name for Strep pneumoniae

A

Pneumococcal

46
Q

Chest infection associated with keeping sheep

A

Coxiella burnetti

47
Q

What type of gram stain do chlamydiae organisms (Chlamydophila psittaci) have?

A

They are obligate intracellular parasites but have a similar wall to gram negatives

48
Q

What type of gram stain does Legionella pneumophila have?

A

Gram negative

49
Q

What type of gram stain does Coxiella burnetti have?

A

Gram negative

50
Q

What organism is associated with eating beef and BBQs

51
Q

What organism is associated with bakeries / cream cakes?

A

Staph Aureus (because it enters the cake products from the hands of the workers)

52
Q

What are the most common organisms that cause early prosthetic valve endocarditis (< 2 months)?

A

S. epidermidis 28.1%
S. aureus 18.8%
S. viridans 3.1%

53
Q

What are the most common organisms that cause late prosthetic valve endocarditis (> 2 months)?

A

S. epidermidis 20.4%
S. aureus 19.4%
S. viridans 15.7%

54
Q

What are the most common organisms that cause native valve infective endocarditis?

A

Acute: Staph Aureus
Subacute: Staph Viridans, Enterococcus faecalis

Others: Staph Epidermidis

55
Q

What are the most common valves affected in infective endocarditis?

A

Tricuspid 50%
Mitral 20%
Aortic 20%

56
Q

A common pneumonia from drunk people aspirating?

A

Klebsiella

57
Q

Most common causes of meningitis?

A

Pneumococcus (Strep pneumoniae)

Meningococcus (Neisseria meningitidis)

58
Q

Most common cause of meningitis >60 years old?

A

Listeria monocytogenes

59
Q

Most common causes of encephalitis?

A

Herpes simplex

60
Q

Most common causes of epiglottitis?

A

Haemophilus influenzae, Streptococci

61
Q

Most common cause of tonsillitis?

A

Strep pyogenes

62
Q

Most common cause of sinusitis?

A

Pneumococcus

63
Q

Most common causes of acute otitis media?

A

Pneumococcus, Haemophilus influenzae

64
Q

Most common causes of Mild/Moderate Community Acquired Pneumonia?

A

Pneumococcus, Haemophilus influenzae

65
Q

Most common causes of Severe Community Acquired Pneumonia?

A

Pneumococcus, Haemophilus influenzae
And possible coliforms and atypicals such as Legionella, Mycoplasma, Chlamydia pneumoniae, Coxiella.

Staph Aureus is common post influenza

66
Q

Most common causes of COPD exacerbation?

A

Pneumococcus, Haemophilus influenzae

67
Q

Most common causes of Hospital Acquired Pneumonia?

A

Pneumococcus, Haemophilus influenzae and coliforms. Legionella can be hospital acquired.

68
Q

Most common causes of peritonitis/ biliary tract sepsis?

A

Polymicrobial coliforms, anaerobes & enterococci

69
Q

Most common causes of UTIs (male and female)?

A

Coliforms, Enterococci

70
Q

Most common causes of pyelonephritis?

A

Coliforms, Pseudomonas aeruginosa, Enterococci

71
Q

Most common causes of urosepsis?

A

Coliforms, Pseudomonas aeruginosa, Enterococci

72
Q

Most common causes of cellulitis?

A

Staph aureus, Strep pyogenes

73
Q

Most common causes of infection in a diabetic foot ulcer?

A

Staph aureus

74
Q

Most common causes of septic arthritis?

A

Staph aureus

75
Q

Most common causes ofosteomyelitis?

A

Staph aureus

76
Q

What organism most commonly causes “rice water stools”

77
Q

What virus causes Chickenpox and Shingles?

A

Varicella Zoster Virus (VZV)

78
Q

What organism causes Syphilis?

A

Treponema pallidum

79
Q

What virus causes erythema infectiosum “slapped cheek disease”?

A

Parovirus B19

80
Q

What organisms cause “Farmers lung”?

A 
Aspergillus 
Saccharopolyspora rectivirgula (bacteria)

Both often found in hay / mould

Saccharopolyspora rectivirgula produces IgG antibodies> Type IV hypersensitivity

81
Q

What organism is associated with a stone associated UTI

A

Proteus sp.

82
Q

Where is Staph epidermidis most commonly found?

A

Skin and mucous membranes

83
Q

Where is Staph aureus most commonly found?

A

Mainly nose and perineum

84
Q

What toxins does Strep pyogenes produce?

A

Pyrogenic exotoxins (SpeB, SpeC)

85
Q

What two organisms are associated with toxic shock?

A

Staph aureus

Strep pyogenes

86
Q

What two organisms are associated with impetigo?

A

Staph aureus

Strep pyogenes

87
Q

What organism causes scabies?

A

Saroptes scabiei

88
Q

What organisms cause Tinea fungal infections?

A
  1. Trichophyton rubrum (>70%)
  2. Tichophyton menagraphytes (20%)
  3. Microsporum canis (rare, from cats/dogs)
89
Q

What conditions warrant a patient getting their own room for precautionary measures?

A

Strep “A” pyogenes infections
MRSA infections
Scabies

90
Q

What organisms cause Candida intertrigo (infection)

A

Candida albicans

91
Q

Tinea capitis

92
Q

Tinea barbae

93
Q

Tinea corporis

94
Q

Tinea mannum

95
Q

Tinea unguium

96
Q

Tinea cruris

97
Q

Tinea pedis

A

Foot (athlete’s)

98
Q

Pediculus humanus capitis

99
Q

Pediculus humanus humanus (corporis)

A

Body lice (Vagabond’s disease)

100
Q

Phthirus pubis

A

Pubic lice / crabs

101
Q

What viruses cause Herpangina?

A

Coxackie virus

Echovirus

102
Q

Causes of erythema multiform?

A

Bacteria- Mycoplasma pneumoniae from lungs

Virus- Herpes

103
Q

What viruses cause Hand, Foot and Mouth Disease?

A

Enteroviruses, Coxackie

104
Q

What organism causes Lyme disease?

A

Borrelia burgdoferi

105
Q

What’s the vector for Lyme disease?

106
Q

What virus causes Orf?

A

Parapox virus

107
Q

Most severe parasite that causes Malaria

A

Plasmodium falciparum

108
Q

Vector that transfers malarial parasite

A

Female Anopheles mosquito

109
Q

Name the organism that produces urease, then breaks down to urea (increasing urinary pH)

It smells foul like burnt chocolate

A

Proteus sp.

110
Q

Associated with catheters and instrumentation

A

Pseudomonas aeruginosa

111
Q

Most likely organism to infect peritoneal dialysis

A

Staph epidermidis

antibiotics (2 decks)

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