Antibiotics: Mechanisms of resistance Flashcards

1
Q

trimethoprim

A

resistant DHFR

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2
Q

penicillin

A

hydrolysis of B-lactam ring by B-lactamase
decreased cephalosporins perm of bacteria to antibiotic
altered PBP

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3
Q

methicillin

A

altered PBPs

B-lactamase resistant

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4
Q

aminoglycosides

A

enz mod by plasmid-coded enz
decreased perm
mutation alters site to which antibiotic binds

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5
Q

tetracycline

A

interference with drug transport into cell

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6
Q

chloramphenicol

A

detox of drug by acetylation of hydroxyl

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7
Q

erythromycin

A

enz methylation of 23S ribosomal RNA

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8
Q

ciprofloxacin/rifampin

A

altered target enz (gyrase, RNAP)

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9
Q

vancomycin

A

alteration of cell wall precursor target

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