Antibiotics: Mechanisms of resistance Flashcards
1
Q
trimethoprim
A
resistant DHFR
2
Q
penicillin
A
hydrolysis of B-lactam ring by B-lactamase
decreased cephalosporins perm of bacteria to antibiotic
altered PBP
3
Q
methicillin
A
altered PBPs
B-lactamase resistant
4
Q
aminoglycosides
A
enz mod by plasmid-coded enz
decreased perm
mutation alters site to which antibiotic binds
5
Q
tetracycline
A
interference with drug transport into cell
6
Q
chloramphenicol
A
detox of drug by acetylation of hydroxyl
7
Q
erythromycin
A
enz methylation of 23S ribosomal RNA
8
Q
ciprofloxacin/rifampin
A
altered target enz (gyrase, RNAP)
9
Q
vancomycin
A
alteration of cell wall precursor target