Antibiotics Flashcards

1
Q

Pencillin G

A

IV route

pharyngitis, syphillis, neisseria, C. Perfringens,
Corynebacterium diphtheria

Gram-positive cocci, gram positive rods

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2
Q

Pencillin V

A

PO

Minor infections

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3
Q

Methicillin

A

Bind to PBP

Inhibit cell wall synthesis

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4
Q

Nafcillin

A

Staphylococcus aureus

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5
Q

Oxacillin

A

Beta-lactamase stable

Anti-staph

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6
Q

Dicloxacillin

A

PO

Follow-up to beta-lactamase stable penicillin ex. Oxacillin

Staphylococcus aureus

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7
Q

Amoxicillin

A
Otitis
Acute sinusitis 
Haemophilius influenza
E. Coli 
Proteus 
Salmonella 
Shigella
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8
Q

Ampicillin

A

Enterococcus

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9
Q

Ampicillin/sulbactam

A

Unasyn
IV

CAP, intra-abdominal infections, S/SI, DM foot, cat/human/dog bites

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10
Q

Amoxicillin/clavulanate

A

Augmentin
PO

2nd line for otitis
Cellulitis
DFI

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11
Q

Piperacillin/tazobactam

A

Zosyn

Pseudomonal activity 
Nosocomial infections 
Serious intra-abdominal infections 
P. Aeurginosa 
K. Pneumoniae
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12
Q

Ticarcillin/calvulanate

A

Treats P. Aeruginosa

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13
Q

Pencillin Group

A

Binds to pencillin binding protein

Inhibits cell wall synthesis

Beta-lactams

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14
Q

Sulbactam

A

Beta-lactamase inhibitor

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15
Q

Tazabactam

A

Beta-lactamase inhibitor

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16
Q

Pencillin Adverse Reactions

A

Rashes/allergic reaction

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17
Q

Cephalosporins

A

Bind to pencillin protein

Inhibit cell wall synthesis

Broader activity than penicillin

Beta-Lactams

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18
Q

Cephalosporin Adverse reactions

A

Rashes
Allergic reactions
Rare: hemolytic anemia

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19
Q

Cefazolin

A

“Ancef” “Kefzol”

IV

Surgical prophylaxis
S/SI 
Staphylococci
Streptococci 
MRSA 
1st generation
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20
Q

Cephalexin

A

“Keflex”

PO

Skin/soft tissue infection 
CAP 
Early DFI
Staphylococci 
Streptococci 
MRSA 
1st generation
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21
Q

Cefaclor

A

2nd generation

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22
Q

Cefporzil

A

“Cefzil”

PO

2nd generation
2nd line for otitis
CAP
S/SI

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23
Q

Cefotetan

A

“Cefotetan”

2nd generation 
Intra-abdominal surgery 
Prophylaxis 
anaerobes Gram positive
Anaerobes Gram negative
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24
Q

Cefuroxime

A

Haemophilus Influenza

2nd generation

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25
Cefoxitin
2nd generation Bacteroides fragilis
26
Cefadroxil
1st generation
27
Ceftriaxone
“Rocephin” IV/IM ``` CAP S/SI Meningitis E. Coli Klebsiella Proteus Neisseria gonorrhoeae 3rd generation ```
28
Cefdinir
3rd generation
29
Cefotaxime
“Claforan” ``` IV CAP S/SI Meningitis 3rd generation ```
30
Ceftazidime
“Fortaz” IV ``` Nosocomial pneumonia Anti-pseudomonal activity Pseudomonas aeruginosa Gram-negative rods 3rd generation ```
31
Cefixime
3rd generation
32
Cefepime
Enteric gram-negative rods that produce extended-spectrum beta-lactamases Staphylococcus aureus (not MRSA) Penicillin-resistant Streptococcus pneumoniae 4th generation
33
Ceftaroline
Gram positive cocci and gram negative rods that cause bacterial pneumonia and skin infections (including MRSA) 5th generation
34
Carbapenems
Binds to penicillin binding protein Inhibit cell wall synthesis Beta-lactams Beta-lactamase stable Generally broader activity
35
Meropenem
“Merrem” IV Anti-pseudomonal activity Nosocomial infections Meningitis
36
Cephalosporins List
``` Cefazolin Cephalexin Cefadroxil Cefaclor Crefporzil Cefotetan Cefuroxime Cefoxitin Ceftriaxone Ceftazidime Cefixime Cefepime Ceftaroline ```
37
Carbapenems List
Meropenem Imipenem/cillistain Ertapenam
38
meropenem
“Merrem” IV Beta-lactamase stable Anti-pseudomonal Nosocomial infections Meningitis
39
Imipenem/cillistain
“Primaxin” IM Beta-lactamase stable ``` Anti-pseudomonal Serious intra-abdominal infections NO MENINGITIS Staphylococcus aureus (NOT MRSA) Pseudomonas aeruginosa Mixed aerobic-anaerobic infections Febrile neutropenia patient ```
40
Ertapenam
“Invanz” IV/IM Beta-lactamase stable CAP DFI S/SI Intra-abdominal infections
41
Monobactams List
Aztreonam Beta-Lactam group
42
Aztreonam
“Azactam” IV/IM Binds to PBP Inhibits cell synthesis Nosocomial infections Strictly gram-negative
43
Imipenem/cillilstain | Adverse Reactions
Seizures in patients with meningitis and diminished renal function
44
Glycopeptides List
Vancomycin Telavancin
45
Glycopeptides
Cell wall inhibitors
46
Vancomycin
Clostridium Difficile
47
Lipopeptides List
Daptomycin
48
Fofsymycin
Cell synthesis inhibitor
49
Tetracylclines List
Doxycycline Tetracycline Minocycline Protein synthesis inhibitors
50
Aminoglycosides List
Amikacin Tobramycin Gentamycin Neomycin
51
Aminoglycosides
Binds irreversibly to 30S ribosome Inhibits protein synthesis Need patient weight and renal function
52
Amikacin
“Amkin” Last line of defense=reserved for resistant organisms Sepsis Pneumonia Wounds Intra-abdominal Genitourinary S/S structure UTI in men
53
Amikacin Adverse Reactions
Ototoxicity Nephrotoxicity Neuromuscular blockade
54
Tobramycin
“Nebcin” IV or IM Same as gentacicin Reserved if organisms are resistant to gentacinin 1st line of defense for pseudomonas
55
Gentamycin
“Garamycin” IV or IM Sepsis Pneumonia wounds Intra-abdominal GI/U S/S structure men with UTI
56
Neomycin
Binds irreversibly to 30S ribosomes
57
Macolides List
Erythromycin Azithromycin Clarithromycin Binds to 50S sub-unit ribosomes Inhibits protein synthesis
58
Erythromycin
outpatient treatment for CAP Streptococcal infections Corynebacterium diphtheriae
59
Macolides Adverse Reactions
GI issues like diarrhea QT prolongation
60
Azithromycin
“Zithromax” PO or IV Outpatient treatment of CAP Otitis Chlaymidia Inpt w/ cephalosporin for CAP IV alone for CAP Campylobacter jejuni
61
Clarithromycin
“Biaxin” PO Output treatment of CAP, S/SI sinusitis Peptic ulcer disease
62
Clindamycin
Inhibits protein synthesis Binds to 50S sub-unit ribosome S/SI Toxic shock syndrome Early DFI Aspiration pneumonia w/ drug for GNR
63
Fluoroquinolone
“Ciprofloxacin” Anthrax Shigella (severe cases)