Antibiotics Flashcards
Memorize the key concepts of antibiotics when prescribing. Learning specific antibiotic classes, bacteria and identify which antibiotics or which bacterial infections.
List Gram + Bacteria
- ) Staph
- ) Strept
- ) Enterococcus
- ) Listeria
- ) Propionbacterium
- ) Corynebacterium (diptheria)
- ) Clostridium
- ) Tetanus, Botulism
- ) Bacillus anthracis
List Gram Negative Bacteria
Just about Everything Else
- ) Neisseria gonorrhoeae
- ) Neisseria menngitidis
- ) E Coli, Shigella, Campylobactor
- ) Salmonella, Pasturella
- ) Rickettsia, Borrelia
- ) Proteus, Pseudomonas, Legionella
List atypical Gram Negative Bacteria
Mycoplasma
H.Flu
M.Cat
Legionella
List Staphylococcus Gram Positive Bacteria
Staphylococcus aureus (skin) MSSA (Staphylococcus aureus) (skin) MRSA (staphylococcus aureus (skin) Staph saprophyticus (UTI, Vagina) Staph epidermis (skin)
What are the Gram Positive Streptococcus Bacteria
Strept pyogens (throat) Strept pneumoniae (lungs) Strept viridans (dental abscess, endocarditis) Strept agalactiae (Group B Strept)
What are the 2 Concepts of “Empiric Treatment”
- ) Consider the difference between Gram Positive and Gram Negative Bacteria
- ) Consider Beta Lactam Ring
Define the meaning of “Beta Lactam”
- ) An antibiotic with a beta-lactam ring
2. ) All PCN and Cephalosporins
When prescribing PCN or Cephalosporin what 2 Points are ALWAYS considered?
- ) Hx of Allergic reactions
2. ) Beta Lactamase antibiotic
Can patients with allergy to PCN take a Cephalosporin
- ) Consider patient allergy to PCN
- ) Both PCN and Cephalo share beta lactamase but allergy to PCN is an allergy to the “pink pentagon” component of the PCN molecule. This differs from the “blue hexagon” of the cephalo molecule
- ) 90-98% of PCN allergy pts are allergic to the “pink pentagon” AND can safely take cephalosporin
- ) 2-10% of PCN allergy patients are ALSO allergic to the “blue hexagon” on the cephalo molecule therefore are allergic to both
What are “Amelie’s Rules” for Prescribing a Cephalosporin
- ) NEVER give cephalo if PCN allergy was anaphylaxis
- ) Don’t give cephalo if PCN reaction was hives
- ) GIVE cephalo is PCN reaction was morbilliform rash
This rash is…
Maculopapular or macular with fixed lesions and expands over several days
Itches
Prevalent most in kids
Most common with aminopenicillins (amox & ampicillin)
Morbiilliform Rash
This rash is usually T Cell mediated
This rash may arise after concurrent viral infections
Unknown mechanism of occurence
Morbilliform Rash
This is an enzyme in which bacteria know how to produce
Beta-Lactamase
What does Beta-Lactamase Do?
Beta Lactamase destroys the beta-lactam ring of the antibiotic
What Bacteria are PCNs USED for..
Gram + NOT Staphylococcus Strep Groups: A,B,C,G Enterococcus Strept pneumonaie Drug Resistant Strep Pneumo (DRSP) Botulism (wound, not food)
Describe Extended Spectrum PENICILLINS
Augmentin (Amoxicillin/Clavulanic acid)
Gram + and Gram Negatives
NOT MRSA
Yes Beta Lactamase
List the Bacteria that Augmentin is SENSITIVE to
Gram + Strep Group A,B,C,G Enterococcus Strept pneumoniae DRSP MSSA
Gram Neg
H. Flu, M. Cat.,
E.coli, Neisseria,
Cornybacterium diptheria
Bactrim is what type of Antibiotic
Sulfonamide
What Bacteria is Bactrim Sensitive to?
Gram Negatives… NOT Strept, NOT e coli
Gram +….. Staph: MSSA, MRSA, CA-MRSA
Name 3 common tetracyclines
Doxycycline, Minocycline and Vibramycin
List Gram Neg Bacteria that tetracycline in sensitive to
Atypical Gram Neg (mycoplasma, M Cat)
H Flu, E Coli, Legionella, Chlamydophila, Rickettsia)
List Gram + bacteria tetracycline sensitive to
MSSA & CA-MRSA
Doxy & Mino *** Good choice for atypical pathogens and lower resp. tract pathogens
Describe 1st Generation Cephalosporin & what Bacteria is sensitive to?
Cephalexin (Keflex), Cefadroxil (Duricef)
Gram +
Staph MSSA
Strept
Describe 2nd Generation Cephalosporin & what Bacteria is sensitive to?
Cefuroxime (Ceftin), Cefaclor (Ceclor) & Cefprozil (Cefzil)
Gram +
Staph MSSA
Streptococcus
Gram Neg
H Flu, E. Coli,
proteus mirabilis
Describe 3rd Generation Cephalosporin & what Bacteria is sensitive to?
Ceftibuten (Cedax) & Cefixime (Suprax)
Weak Gram +
Strept Groups
Not Staph
Gram Neg
H Flu, M Cat, E Coli
Klebsiella, Salmonella and Shigella
Describe Extended Spectrum 3rd Generation & What Bacteria is Sensitive to?
Ceftriaxone (Rocephin), Cefdinir (Omnicef), Cefpodoxime (Vantin) & Cefditoren (Spectracef)
AND Beta Lactamase Producers
Gram +
Strept
Staph:MSSA
Gram Neg: H Flu, M. Cat, E. Coli, Salmonella, Shigella & Proteus mirabilis
Describe early Generation Macrolide and Bacteria Sensitive to?
Erythromycin
Atypical Pathogens
NOT Staph, Not Strept, Not Enterococcus
Listeria
Gram Neg: M. Cat, Legionella, Chlamydophilia, Mycoplasma
Describe Later Generation Macrolide and Bacteria Sensitive to
Azithromycin (Zithromax), Clarithromycin (Biaxin)
Atypical Pathogens
Gram + NOT Strept NOT Enterococcus Staph: MSSA Listeria
Gram Neg: M. Cat, Legionella, Chlamydophilia, Mycoplasma
Describe 2nd Generation Fluoroquinolones and Bacteria Sensitive to..
Ciprofloxacin (Cipro)
Gram Neg: M. Cat., H. Flu, E Coli, Legionella, Chlamydophila, Mycoplasma, Klebsiella, Anthrax, Other Gram Neg.
Gram +
Staph MSSA
NOT Strept
Not Enterococcus
Describe Respiratory Fluoroquinolones 3rd generation and Bacteria Sensitive to…
Levofloxacn (Levaquin)
Gram +
Staph MSSA
Listeria
Gram Neg.
Strept: all, M. Cat, H. flu, E. Coli, Legionella, Chlamydophila, Mycoplasma, Klebsiella, +/- pseudomonas
Describe Fluoroquinolones 4th Generation and Bacteria Sensitive to…
Moxifloxacin (Avelox), Gemifloxacin (Factive) & Gatifloxacin (Zymar ophth)
Gram + Staph: MSSA Listeria Not URINARY pathogens DRSP
Gram Neg (above the belt) Strep: All Spec., M. Cat, H. Flu, E. coli, Legionella, Chlamydophila, Mycoplasma, Klebsiella
Atypical Pathogens
**GI Pathogen Coverage
Describe Miscellaneous antibiotic that concentrate in bladder and Bacteria Sensitive to
Nitrofurantoin (Macrobid)
Urinary Pathogens
Gram +
MSSA
CA-MRSA (Usually)
Streptococcus
Gram Neg: E.coli
Describe Miscellaneous Antibiotic and Bacteria Sensitive to
*Hint: Anaerobes only
Metronidazole (Flagyl)
C Diff
Clostridium sp.
**Clostridium is gram +
Describe the antibiotic that can be used for Gram +, Gram Neg, Aerobes and Anaerobes
Lincosamide (Clindamycin) Gram + MSSA, CA-MRSA (Usually) Streptococcus
This is a misc. antibiotic that is used for Gram + Bacteria only
Linezolid (Zyvox) Gram + MSSA MRSA CA-MRSA Streptococcus Enterococcus Listeria
What is the antibiotic that is a Glycopeptide and what Bacteria Sensitive to
**Hint Sensitive to Anaerobes
Vancomycin
Gram + MSSA MRSA CA-MRSA (Usually) Streptococcus
Gram Neg.
C. difficile (oral)